Biomolecular Structure Center
University of Washington School of Medicine

Selected Projects

Structure-Based Drug Design

Structure-based drug design (SBDD) is an iterative approach to the discovery of potential new drugs. It depends on extensive interaction and collaboration among molecular and structural biologists, synthetic and theoretical chemists. Many of the research projects at the UW Biomolecular Structure Center use this approach to target specific diseases, particularly those caused by tropical parasites.

Structural Genomics of Pathogenic Protozoa

The SGPP consortium is one of 9 Structural Genomics funded by the NIH to develop new technologies for high-throughput protein expression and structure determination. The specific targets of the SGPP effort are proteins from the disease-causing organisms Leishmania major, Trypanosoma brucei, Trypanosoma cruzi and Plasmodium falciparum.

Cholera toxin project

Crystallographic studies of E. coli heat-labile enterotoxin (LT) and other members of the Cholera toxin (CT) family of AB5 bacterial toxins.
Toxin project publications
Toxin project journal covers

Human blood coagulation factor XIII

Crystallographic studies of a transglutaminase.

Diphtheria toxin repressor

Crystallographic studies of an [Fe]-regulated DNA binding protein.


Investigations of the structural basis for the extreme binding affinity between streptavidin and biotin

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