| LECTURES |
1988
12/07: Annual symposium of Medicinal Chemistry - University of Antwerp,
Belgium
The kappa-opioid pharmacophore in 6,7-benzomorphans
1989
11/30: Biotechnology course - University of Nijmegen, The Netherlands
(Host: Dr. Ruud Konings)
Molecular modeling: principles and applications
1990
01/12: BIOS Lecture - University of Groningen, The Netherlands
Towards new sleeping sickness drugs by structure-based
drug design
07/13: Protein Structural Aspects of Biotechnology. COMETT Advanced
Course - University of Nijmegen, The Netherlands (invited speaker)
Protein engineering and drug design
11/26: 2nd Symposium on Biochemical Biotechnology - Villa Olmo, Como,
Italy (Invited speaker)
Ab initio design of selective inhibitors of
trypanosomal triosephosphate isomerase: toward new drugs against sleeping
sickness
1991
04/15: INTERNATIONAL ORGANIZATION FOR CHEMISTRY IN DEVELOPMENT Meeting
- Institute for Cellular Pathology, Brussels, Belgium (Host: Dr. Fred Opperdoes)
Rational design of anti-trypanosomal agents
06/10: University Centre for Pharmacy RUG - Groningen, The Netherlands
(Host: Dr. Alan Horn)
The linked-fragment approach as a tool for
inhibitor design: towards new drugs against trypanosomiasis
1992
None: due to relocation
1993
03/25: Seattle Protozoology Conference - Seattle, WA
Successful rational selective inhibition of
a trypanosomal enzyme
05/27: Annual meeting of the American Crystallographic Association -
Albuquerque, NM
Successful rational selective inhibition of
a trypanosomal enzyme
08/19: Department of Pharmaceutical Sciences UCSF (Host: Dr. Irwin Kuntz)
Protein structure-based design for selective
inhibition of glyceraldehyde-3-phosphate dehydrogenase: towards new drugs
for the treatment of sleeping sickness
09/12: Albany Conference: Molecular Mechanisms of Drug Resistance -
Rensselaerville, NY (Invited speaker)
Drug design in protozoa
09/16: BIOSYM Scientific Seminar Series - Seattle, WA(Invited speaker)
Successful rational selective inhibition of
a trypanosomal enzyme
11/22: BASF - Ludwigshafen, Germany (Host: Dr. Hans-Joachim Boehm)
Protein structure-based drug design: from
an aspecific lead to a 500-fold gain in selectivity
1994
02/25: Department of Biological Structure Seminar - Seattle , WA
Protein structure-based inhibitor design for
tropical diseases
04/11: The third Pacific Northwest Protein Crystallography Workshop
- Seattle
Protein structure-based inhibitor design:
expectations and facts
07/27: 3rd International satellite meeting: on the conformational analysis
of carbohydrates & protein/carbohydrate interactions - Val Morin, Canada
(Invited speaker)
Characterization of the carbohydrate receptor
site in the cholera toxin family and its exploitation for drug design
09/02: 15th European Crystallographic Meeting - Dresden, Germany (Invited
speaker)
Selective protein structure-based drug design:toward
new drugs for the treatment of sleeping sickness
1995
01/20: Faculty Candidate Seminar - University of Washington, Seattle,
WA
Protein structure-based drug design: fact
or fiction?
02/09: Looking at protein structures and nucleic acids - University
of Leuven, Belgium (Invited speaker)
Towards new drugs against trypanosomiasis
and cholera: drug design on the basis of protein structures
05/24: 36th Annual Buffalo Medicinal Chemistry Symposium - Buffalo (Session
organizer and speaker)
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate
dehydrogenase by protein structure-based drug design: toward new drugs
for the treatment of sleeping sickness
07/28: Annual meeting of the American Crystallographic Association -
Montreal (Session organizer and speaker)
Protein structure-based drug design: progress,
results and challenges
1996
03/01/96: Medicinal Chemistry Seminar - University of Washington, Seattle
(Host: Dr. Valerie Daggett)
Structure-based drug design: recipes for success
04/17/96: Biochemistry Dept., Wake Forest University, Winston-Salem,
NC (Host: Dr. Al Claiborne)
Structure-based Drug Design for Tropical Diseases
04/19/96: 4th Bud Suddath Memorial Symposium - Georgia Institute of
Technology, Atlanta (Host: Dr. Jim Powers)
Structure-based Drug Design for Tropical Diseases
04/26/96: UAB Structure-based drug design Conference - Panama City Beach
(Invited speaker)
Structure-Based Optimization of Poor Leads:
From high millimolar to low micromolar inhibitors
1997
01/28: UW Computer Science & Engineering (Host: Dr. Richard Karp;
televised on UW TV channel)
Computational and algorithmic challenges in
structure-based drug design
07/29: 662nd British Biochemical Society Meeting - Dundee, Schotland
(Invited speaker)
Selective inhibition of glycolysis in tropical
parasites by structure-based drug design
08/01: University of York, Department of Chemistry - York,UK (Host:
Dr. Koen Verschueren)
Selective inhibition of glycolysis in tropical
parasites by structure-based drug design
08/04: University of Leicester, Department of Biochemistry - Leicester,
UK (Host: Dr. Tina Izard)
Selective inhibition of glycolysis in tropical
parasites by structure-based drug design
09/11: American Chemical Society Meeting - Las Vegas (Invited speaker)
Anchor-based drug design
1998
12/07: INABIS (Internet Association for BIomedical Sciences) '98: 5th
Internet World Congress on Biomedical Sciences (Invited speaker)
Five Orders of Magnitude Affinity Gain in
Anti-trypanosomal Drug Development
available from URL: http://www.mcmaster.ca/inabis98/pharmtox/verlinde0900/index.html
1999
01/25: University of British Columbia, Department of Biochemistry and
Molecular Biology - Vancouver, Canada (Host: Dr. Michael Murphy)
Five Orders of Magnitude Affinity Gain in
Anti-trypanosomal Drug Development by Structure-based Design
03/23: DowAgrochemicals, Indianapolis, IN (Host:
Dr. Terry Walsh)
Five Orders Affinity Gain by Selective Structure-based
Design
05/25: Annual meeting of the American Crystallographic Association -
Buffalo
Five Orders of Magnitude Affinity Gain in
Anti-trypanosomal Drug Development by Structure-based Design
06/03: General Meeting of the American Society of Microbiology - Chicago
(Invited speaker)
Structure-based Drug Design
10/21: Christan de Duve Institute of Cellular Pathology - Universite
Catholique de Louvain - Belgium (Host: Dr. Paul Michels)
Structure-based strategies for disabling cholera
toxin and heat-labile enterotoxin, masters of cellular trafficking
11/10: Eli-Lilly - Indianapolis (Host: Dr. Genshi Zhao)
Five Orders of Magnitude Affinity Gain in
Anti-trypanosomal Drug Development by Structure-based Design
2000
04/19: UW Biophysics Seminar
A new and fast molecular docking approach:
stochastic approximation with smoothing
2001
01/17: Nortwestern University - Chicago (Host: Dr. Brian Shoichet)
A new and fast molecular docking approach:
stochastic approximation with smoothing
6/20: "Modeling of protein interactions in genomes", Charleston, SC
(Invited speaker)
A new and fast molecular docking approach:
stochastic approximation with smoothing
7/23: Structural GenomiX, San Diego, CA (Host: Dr. Mike Milburn)
Structure-based design: a case study and a
new algorithm
8/26: ACS National Meeting Chicago (Invited speaker)
A new and fast molecular docking approach:
stochastic approximation with smoothing
11/11: 1st Brazilian Symposium on Medicinal Chemistry "New apporaches
in drug design" Caxambu, Minas Gerais, Brazil (Invited keynote speaker)
Protein structure-based design of antiprotozoal
drugs
2002-2004
None, due to long term hospitalization and slow recovery. Healthy now!
2005
11/11-12: Amauta 3rd International Course on Biomedical and Health Informatics, Lima, Peru
(Invited speaker)
Protein structure-based design: methods and practice
| POSTERS |
03/25/83: X-ray Crystallography and Drug Design - Erice, Sicily, Italy
Putative kappa-agonists: The crystal structure
of ketazocine
08/11/83: 8th European Crystallography Meeting - Liege, Belgium
Putative kappa-agonists and the role of oxygen
01/11/83: SON Crystallography Meeting - Lunteren, The Netherlands
Structures of benzomorphan kappa-agonists
06/13/84: 25th Annual Medicinal Chemistry Symposium - Buffalo, NY
The opioid kappa-pharmacophore in benzomorphans:
PCILO calculations of electronic properties and proton affinities, and
molecular modeling
04/15/85: SON Crystallography Meeting - Lunteren, The Netherlands
Molecular mechanics: N-C-C-O torsional parameters
in MM2. Crystal structures and CNDO/2 calculations
09/05/85: 9th European Crystallographic Meeting - Torino, Italy
The role of an extra oxygen atom in the opioid
kappa pharmacophore of some benzomorphans
04/13/87: SON Crystallography Meeting - Lunteren, The Netherlands
Interpretation of static disorder: MM2 pucker
analysis of a 2,2-disubstituted tetrahydrofuran ring
06/07/89: Three-dimensional Molecular Structure and Drug Design. A NATO
Advanced Study Institute - Erice, Sicily, Italy
The sleeping sickness project
08/15/89: Prospects in Protein Engineering - Haren, The Netherlands
Protein structure-based design of new drugs
against sleeping sickness
12/11/89: SON Protein Research Meeting - Lunteren, The Netherlands
Ab initio design of selectivity for gTIM inhibitors:
potential drugs against sleeping sickness
12/10/90: SON Protein Research Meeting - Lunteren, The Netherlands
Progress in the design of inhibitors of the
glycolytic enzymes of Trypanosoma brucei, the causative agent of sleeping
sickness
09/11/91: 8th Camerino-Noordwijkerhout Symposium - Camerino, Italy
Pharmacological, structural and pharmacological
analysis of 6,7-benzomorphans with kappa-agonistic activity. Modeling of
the kappa-opioid pharmacophore
12/09/91: SON Protein Research Meeting - Lunteren, The Netherlands
Towards selective gGAPDH inhibitors: protein
structure-based design
08/05/92: European Crystallographic Meeting, Enschede, The Netherlands
Protein structure-based inhibitor design:
towards new drugs for trypanosomiasis
08/12/92: ACA Meeting, Pittsburgh, PA
Protein structure-based inhibitor design:
towards new drugs for trypanosomiasis
03/14/95: 12th West Coast Protein Crystallography Workshop, Asilomar,
CA
Structure-based drug design and tropical diseases
07/08/00: 6th NW Crystallography Workshop, Eugene, OR
A new and fast molecular docking approach:
stochastic approximation with smoothing
10/13/00: UCSF Symposium "Drug design and discovery", San Fransisco,
CA
A new and fast molecular docking approach:
stochastic approximation with smoothing