IN THE NEWS

Our latest paper was the subject of the "Practical Fragments" blog:
Crystallography as a primary screen: the case of HisRS.

Koh C.Y., Kallur Siddaramaiah L., Ranade R., Nguyen J., Jian T., Zhang Z., Gillespie J.R.,
Buckner F.S., Verlinde C.L.M.J., Fan E., Hol W.G.J. (2015). A binding hotspot in the Trypanosoma cruzi
histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Cryst. D71: 1684-1698.

Our latest paper on was the subject of a Nature Structural & Molecular Biology
News and Views (17, 541-543 (2010)) with the title
"A parasite calcium switch and Achilles' heel revealed" .

Ojo K.K., Larson E.T., Keyloun K.R., Castaneda L.J., DeRocher A.E., Inampudi K.K., Kim J.E.,
Arakaki T.L., Murphy R., Zhang L., Maly D.J., Verlinde C.L.M.J., Buckner F.S., Parsons M., Hol
W.G.J., Merritt E.A., Van Voorhis W.C. (2010). A Unique Variation of the ATP binding site makes
Toxoplasma gondii Calcium-Dependent Protein Kinase 1 a drug target for selective kinase inhibitors.
Nature Struct. Mol. Biol. 17: 602-607.


We made it to the cover of Journal of Medicinal Chemistry
from July to December 2008.*

Bulbule V., Rivas K., Verlinde C.L.M.J., Van Voorhis W.C., Gelb M.H. (2008).
2-Oxo-Tetrahydroquinoline-Based Anti-Malarials with High Potency and
Metabolic Stability. J. Med. Chem. 51, 384-387. [PMID: 18198825 ].

* Journal changes cover every 6 months.