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Lectures Given by Wim G.J. Hol

 

Updated:  16 June, 2016
1971
  1. March 18, 1971 - MRC Laboratory Molecular Biology, Cambridge (UK). "A comparison of the structures of subtilisin Novo and BPN'."
  2. March 25, 1971 - Meeting SON Working Group on Proteins, Amsterdam. "The crystal structure of subtilisin Novo and its comparison with subtilisin BPN'."
  3. June 1971 - Cold Spring Harbor Conference on Quantitative Biology (USA). "The crystal structure of subtilisin novo."

1974
  4. September 1974 - Harden Conference - Wye College (UK). "The three-dimensional structure of bovine liver rhodanese."
  5. September 1974 - : Protein Crystal Growth Conference (Leeds, UK). "The successful two-layer technique employed in Groningen for growing single crystals of proteins."

1975
  6. September 1975 - Princeton University, USA. "The three-dimensional structure of bovine liver rhodanese."
  7. September 1975 - Yale University, USA (Host: Prof. Steitz). "The three-dimensional structure of bovine liver rhodanese."
  8. September 1975 - M.I.T. USA (Host: Prof. A. Rich). "The three-dimensional structure of bovine liver rhodanese."
  9. October 1975 - Chicago University, USA (Host: Prof. Heinrikson). "The three-dimensional structure of bovine liver rhodanese."
 10. October 1975 - : University of California, San Diego, USA (Host: Prof. Kraut). "The three-dimensional structure of bovine liver rhodanese."

1976
 11. July 1976 - Biozentrum, Basel (Host: Prof. Jansonius). "The three-dimensional structure of bovine liver rhodanese."

1977
 12. February 1977 - University of California, San Diego, USA. "The structure of bovine liver rhodanese and the role of the α-helix dipole in the binding of nucleotides."
 13. February 1977 - : American Crystallographic Association, Assilomar, USA. "The structure of bovine liver rhodanese and the role of the α-helix dipole in the binding of nucleotides."
 14. March 1977 - University of Oregon, Eugene (USA). (Host: Prof. B.W. Matthews). "The structure of bovine liver rhodanese and the role of the α-helix dipole in the binding of nucleotides."
 15. March 1977 - University of North Carolina, Chapel Hill, USA (Host: Prof. J. Hermans). "The structure of bovine liver rhodanese and the role of the α-helix dipole in the binding of nucleotides."
 16. March 1977 - Purdue University, Lafayette, USA (Host: Prof. M.G. Rossmann). "A functional explanation of the "Rossmann fold"."
 17. March 1977 - University of Chicago, USA (Host: Prof. Heinrikson). "The structure of bovine liver rhodanese and the role of the α-helix dipole in the binding of nucleotides."
 18. October 1977 - CECAM Discussion Meeting, Bilthoven. "The role of the α-helix dipole in the functioning of proteins."
  19. December 1977 - Catalysis Centre, Groningen. "The role of the α-helix dipole in the functioning of proteins."

1978
 20. September 1978 - CECAM Discussion Meeting, Leiden. "Enzymatic reaction mechanisms suitable for quantum mechanical approaches."

1979
 21. March 1979 - SON Discussion Group "Biomolecular Chemistry" Meeting, Wageningen. "The catalysis of sulfur transfer by the enzyme bovine liver rhodanese."
 22. April 1979 - Lab of Molecular Biology, Oxford, UK (Host: Prof. D.C. Phillips). "The mechanism of rhodanese and the role of the α-helix dipoles in proteins."
 23. April 1979 - MRC Laboratory, Cambridge, UK. "The mechanism of rhodanese and the role of the α-helix dipoles in proteins."
 24. September 1979 - "Conference on New Techniques in Protein Crystallography", Kent, UK. "The α-helix dipole and the properties of proteins."
 25. November 1979 - Biophysical Chemistry, Nijmegen (Host: Prof. C. Hilbers). "The enzyme rhodanese and the electrical dipole of α-helices."
 26. November 1979 - Symposium of the Dutch Society of Biochemistry. "Flexibility of proteins determined by X-ray diffraction."

1980
 27. March 1980 - University of Uppsala, Sweden (Hosts: Prof. B. Strandberg & C. Brändén). "The α-helix dipole and catalysis by proteins." (Two lectures of 45 minutes).
 28. October 1980 - CECAM Discussion Meeting, Amersfoort. "The dipole of the α-helix and the structure of proteins."
 29. October 1980 - Biomolecular Study Centre, Groningen. "The structure and action of phospholipase and prophospholipase."

1981
 30. January 1981 - Biomolecular Study Centre, Groningen. "The dipoles of the α-helix and the β-sheet and their role in the structure of proteins."
 31. April 1981 - Unilever Research Laboratory, Vlaardingen. "The dipoles of the α-helix and the β-sheet and their role in the structure of proteins."
 32. November 1981 - Birkbeck College, London (Host: Prof. T.L. Blundell). "The surprising role of the peptide dipole in the folding and functioning of proteins."

1982
 33. May 1982 - : ZWO Symposium on "Molecular Biology and Medical Sciences" (The Hague). "Rational design of new drugs on the basis of three-dimensional structures of target proteins."
 34. May 1982 - Department of Pharmacy, Groningen. "Rational design of new drugs on the basis of three-dimensional structures of target proteins."
 35. June 1982 - International School of Crystallography, Erice, Italy. "Electrostatic interactions and the folding of proteins."
 36. June 1982 - International School of Crystallography, Erice, Italy. "Molecular dynamics and a completely general description of temperature motions in crystallography."
 37. July 1982 - Gordon Conference on "Diffraction Methods in Molecular Biology", New Hampshire, USA. "Molecular dynamics and a completely general description of temperature motions in crystallography."
 38. July 1982 - Gordon Conference on "Diffraction Methods in Molecular Biology", New Hampshire, USA. "The structure of Panulirus interruptus hemocyanin at 5 Å resolution."
 39. August 1982 - : "American Association of Pharmacology and Experimental Therapeutics" Conference, Louisville, USA. "The structure and catalytic mechanism of bovine liver rhodanese."
 40. September 1982 - Nobel Symposium on Inorganic Biochemistry, Karlskoga, Sweden. "The structure of Panulirus interruptus hemocyanin at 5 Å resolution."
 41. September 1982 - University of Uppsala, Sweden (Host: Prof. C.I. Brändén). "The structure of Panulirus interruptus hemocyanin at 5 Å resolution."
 42. September 1982 - CECAM, Orsay, Paris, Workshop on "Simulation of dinucleotide binding by proteins." "Electrostatic interactions and dinucleotide binding by proteins."
 43. October 1982 - Meeting of SON Working Group on Proteins with Industry, Amsterdam. "Possible applications of fundamental research on proteins for the Dutch chemical industry."
 44. December 1982 - Scientific meeting of SON Working Group on Proteins, Lunteren. "The three-dimensional structure of Panulirus interruptus hemocyanin."

1983
45. March 1983 - Birkbeck College, London (Host: Prof. T.L. Blundell). "The three-dimensional structure of haemocyanin at 3.2 Å resolution."
 46. March 1983 - British Biophysical Discussion Group Meeting on "Electrostatic Interaction in Proteins", London. "The α-helix dipole and the properties and folding of proteins."
 47. March 1983 - Department of Biochemistry, Technical University, Delft. "Three-dimensional structures of proteins: their determination and their application."
 48. March 1983 - International School of Crystallography, Erice, Italy. "The α-helix dipole and the binding of co-enzymes and substrates by proteins."
 49. April 1983 - Gist-Brocades Company, Delft. "Possible applications of protein crystallography for protein engineering and vaccine design."
 50. May 1983 - Organon, Pharmaceutical Division, Oss. "Possible application of protein crystallography for drug and vaccine design."
 51. June 1983 - Biozentrum, Basel (Host: Prof. J.N. Jansonius). "The α-helix dipole and: protein function, protein folding, cancer and drug design."
 52. June 1983 - Hoffmann-La Roche, Basel. "The α-helix dipole and: protein function, protein folding, cancer and drug design."
 53. September 1983 - Colloquium, Department of Biochemistry, University of Amsterdam. "The α-helix dipole and: protein function, protein folding, cancer and drug design."
 54. November 1983 - Scientific Meeting, SON Working Group on "Molecular Genetics", Borger, The Netherlands. "Possible applications of protein crystallography for protein engineering, and drug and vaccine design."
 55. November 1983 - Scientific Meeting, Dutch Working Group on Synthetic Vaccins, Bilthoven, The Netherlands. "Three-dimensional structures of proteins and vaccine design."

1984
 56. March 1984 - Biomolecular Study Centre (BIOS), University of Groningen. "The structure of arthropodan hemocyanins."
 57. April 1984 - Third International Meeting of the Molecular Graphics Society, Royal Holloway College, UK. "The computer graphics system of the protein crystallography group of the University of Groningen."
 58. April/May 1984 - Bürgenstock Conference on Stereochemistry, Switzerland. "The α-helix dipole and: protein function, protein folding, cancer and drug design."
 59. August 1984 - 13th Intl. Congress of Crystallography, Hamburg, West-Germany. "The structure determination of Panulirus interruptus hemocyanin."
 60. November 8, 1984 - 10th Taniguchi Foundation Symposium on Biophysics, Oiso, Japan. "The α-helix dipole and the function and structure of proteins."
 61. November 12, 1984 - Institute of Protein Research, Osaka, Japan (Host: Prof. N. Yasuoka). "The structure of Panulirus interruptus hemocyanin."
 62. November 12, 1984 - Institute of Protein Research, Osaka, Japan (Host: Prof. N. Yasuoka). "The role of the α-helix dipole in the functioning and folding of proteins."
 63. November 13, 1984 - University of Tokyo, Faculty of Pharmaceutical Sciences (Host: Prof. Y. Mitsui). "Effects of α-helix dipole on enzymatic reactions."

1985
 64. February 15-16, 1985 - Study Weekend on Molecular Replacement, Daresbury, UK. "The use of molecular replacement techniques in solving unknown structures related to known structures."
 65. February 15-16, 1985 - Study Weekend on Molecular Replacement, Daresbury, UK. "The use of molecular replacement techniques for phase improvement and extension in the case of hemocyanin."
 66. February 22, 1985 - Geselschaft Deutscher Chemiker, Frankfurt Airport, West-Germany. "Protein Crystallography, Computer Graphics and Drug Design."
 67. March 14, 1985 - Bayer AG, Leverkusen, West-Germany. "Protein crystallography and computer graphics: Drug design for tropical diseases and cancer."
 68. March 29, 1985 - Lecture for the "European Federation of Biotechnology - Working Party on Applied Molecular Genetics", University of Amsterdam. "Protein crystallography and protein engineering."
 69. April 15-20, 1985 - 2nd International Conference on Bioinorganic Chemistry, Algarve, Portugal. "Structure of arthropodan hemocyanins."
 70. May 6, 1985 - Hoechst AG, Frankfurt, West-Germany. "Protein crystallography, computer graphics and drug design."
 71. June 7, 1985 - Biomedical Centre, Uppsala, Sweden (Host: Prof. C.I. Brändén). "Protein Crystallography in Groningen."
 72. June 14, 1985 - Institut für Genetik, Köln, West-Germany (Host: Prof. K. Beyreuther). "Protein Crystallography, Computer Graphics and Drug Design."
 73. July 30, 1985 - Symposium on "Invertebrate Oxygen Carriers", Tutzing, West-Germany. "Three-dimensional structure of hemocyanin from Panulirus interruptus - an arthropod."
 74. September 21, 1985 - International Meeting on "Crystallography in Molecular Biology", Bischenberg, France. "Protein Crystallography and Drug Design."
 75. October 17, 1985 - 2nd European Seminar on Computer Aided Molecular Design, Basel, Switzerland. "Enzyme Action."
 76. December 14, 1985 - Scientific Meeting of SON Working Group on Proteins, Lunteren. "Rational design of drugs against sleeping sickness and import of enzymes into glycosomes."

1986
 77. January 24, 1986 - Meeting on Protein Structure Prediction, Daresbury, UK. "Sequence templates and sequence variability."
 78. February 5, 1986 - : Department of Pharmacy, University of Groningen. "Protein Crystallography and Rational Drug Design."
 79. March 4, 1986 - UNIDO Meeting on Biotechnology, Trieste, Italy. "Protein crystallography and needs of developing countries."
 80. April 7, 1986 - Department of Biology, University of Groningen. "On thermostability of proteins."
 81. May 5, 1986 - International Symposium on Protein Engineering, Paterswolde. "Crystallization of Proteins."
 82. May 8, 1986 - Symposium on Innovations in Drug Design, Zeist. "Protein crystallography and rational drug design, in particular concerning sleeping sickness."
 83. May 16, 1986 - BASF GmbH, Ludwigshafen, West-Germany. "Protein crystallography and rational drug design."
 84. May 22, 1986 - Université Libre de Bruxelles (Host: Dr. S. Wodak). "The α-helix dipole and the action and folding of proteins."
 85. July 7, 1986 - Gaithersburg, Maryland, USA, Centre for Advanced Research in Biotechnology (Host: Dr. K. Ulmer). "Protein crystallography for rational design of drugs against sleeping sickness."
 86. July 21, 1986 - Hemocyanin Workshop, Duke University Marine Laboratory, Beaufort, North Carolina, USA. "Structure of arthropodan hemocyanins."
 87. July 31, 1986 - University of California Los Angeles (Host: Dr. D. Eisenberg). "The α-helix dipole and protein structure and function."
 88. August 4, 1986 - : The Auguron Institute, La Jolla, CA, USA (Host: Dr. D.A. Matthews). "Structure of arthropodan hemocyanins."
 89. August 5, 1986 - Scripps Medical Research Institute, La Jolla, CA, USA (Host: Dr. J. Tainer). "Protein crystallography for rational design of drugs against sleeping sickness."
 90. August 12, 1986 - Purdue University, West Lafayette, IN, USA (Host: Dr. M.G. Rossmann). "Protein crystallography for rational design of drugs against sleeping sickness."
 91. August 21, 1986 - 15th International Symposium of the International Union of Pure and Applied Chemistry (IUPAC), The Hague. "Protein Crystallography, Computer Graphics and rational drug design."
 92. September 4, 1986 - Royal Dutch Chemical Society (KNCV), Summer Congress, Amsterdam. "Which chemistry for the Third World."
 93. September 16, 1986 - European Molecular Biology Laboratory (EMBL), Heidelberg, FRG. "The crucial role of protein crystallography for biophysics, biochemistry and medicine."
 94. September 22, 1986 - Dutch Organization for Applied Scientific Research (TNO), Zeist. "Protein crystallography and the design of new vaccines, enzymes, drugs, insecticides and pesticides."
 95. October 24, 1986 - Section Inorganic and Physical Chemistry of the Royal Dutch Chemical Society, Nijmegen. "Crystallography of Biomacromolecules: importance for biochemistry, biotechnology and medicine."
 96. November 4, 1986 - Max Planck Institut für Biochemie, Martinsried bei München. "Structure and action of hemocyanins."
 97. November 27, 1986 - Dutch Cell Biology Society; Symposium "Morphology of Molecules", Groningen. "The shape of biomacromolecules as basis for designing new drugs."
 98. December 3, 1986 - Organon Pharmaceutical Company, Oss. "Protein Crystallography, Computer Graphics and Rational Drug Design."
 99. December 10, 1986 - BICEPS (Bio-Informatics Collaborative European Programmes and Strategy) Seminar, Brussels, Belgium. "An Academic View on the BICEPS exploratory studies."

1987
100. January 9, 1987 - Royal Dutch Chemical Society, Winter Congress, Amsterdam. "Protein Crystallography, Computer Graphics and the design of new catalysts, vaccines, enzymes and drugs."
101. April 8, 1987 - General Colloquium, Department of Chemistry, University of Nijmegen. "Protein crystallography and computer graphics: importance for biochemistry, biotechnology and medicine."
102. April 13, 1987 - : Scientific Meeting of SON Working Group on Crystallography, Lunteren. "Protein Crystallography and Computer Graphics: its importance for biochemistry, biotechnology and medicine."
103. May 5, 1987 - Postgraduate Course in Biophysics, Liege, Belgium. "New developments in X-ray diffraction."
104. May 15, 1987 - 1st BIOSON Symposium, Groningen. "The structure and evolution of hemocyanins."
105. July 10, 1987 - Third International Conference on Bioinorganic Chemistry (ICBIC-3), Noordwijkerhout. "Structure and evolution of hemocyanins."
106. September 10, 1987 - EMBO Protein Crystallography Course, Uppsala, Sweden. "Structure and evolution of hemocyanins."
107. September 11, 1987 - EMBO Protein Crystallography Course, Uppsala, Sweden. "Locating heavy atom positions."
108. September 11, 1987 - EMBO Protein Crystallography Course, Uppsala, Sweden. "Trypanosome Enzymes."
109. September 20, 1987 - "Second Course on Problems and Methods in Molecular Biology and Biotechnology", Drouzba, Bulgaria. "Protein crystallography, molecular biology and biotechnology."
110. September 20, 1987 - "Second Course on Problems and Methods in Molecular Biology and Biotechnology", Drouzba, Bulgaria. "Protein crystallography, computer graphics and rational drug design."
111. November 3, 1987 - : Royal Danish School of Pharmacy, Copenhagen, Denmark (Host: Prof. F.S. Jorgensen). "Protein Crystallography and Protein Function."
112. November 3, 1987 - Royal Danish School of Pharmacy, Copenhagen, Denmark (Host: Prof. F.S. Jorgensen). "Applications of Protein Structure and Function."
113. November 4, 1987 - Royal Danish School of Pharmacy, Copenhagen, Denmark (Host: Prof. F.S. Jorgensen). "Protein Crystallography, Molecular modelling and the rational design of new sleeping sickness drugs."
114. December 8, 1987 - General Seminar, MRC Laboratory of Molecular Biology, Cambridge, UK. "Protein crystallography and sleeping sickness."
115. December 9, 1987 - British Crystallographic Association Meeting, Oxford, UK. "Protein Crystallography and sleeping sickness."

1988
116. February 12, 1988 - National Cancer Institute, Amsterdam. "Protein crystallography and the rational design of new drugs, in particular concerning trypanosomiasis."
117. February 22, 1988 - B.C.P. Janssen Instituut, University of Amsterdam. "Principles of Protein Engineering."
118. March 12, 1988 - Dept. of Chemistry, University of Colorado, Boulder, USA (Host: Dr. D. McKay). "Structure and evolution of hemocyanins."
119. March 14, 1988 - Dept. of Chemistry, University of Berkeley, CA., USA (Host: Dr. S.H. Kim). "Protein crystallography and the design of new sleeping sickness drugs."
120. March 16, 1988 - School of Medicine, U.C. San Francisco, USA (Host: Dr. P. Kollman). "A FAST structure determination of thermitase, a thermostable subtilisin."
121. March 17, 1988 - Institute of Molecular Biology, UC Los Angeles, USA (Host: Dr. D. Rees). "A FAST structure determination of thermitase, a thermostable subtilisin."
122. March 18, 1988 - Dept. of Biochemistry, UC Riverside, USA (Host: Dr. A. McPherson). "Protein crystallography and the design of new sleeping sickness drugs."
123. March 21, 1988 - Washington University, St. Louis, MO, USA (Host: Dr. F. Scot Mathews). "Structure and evolution of hemocyanins."
124. March 22, 1988 - Johns Hopkins University, Baltimore, USA (Host: Dr. E. Lattmann). "Structure and evolution of hemocyanins."
125. March 23, 1988 - Centre for Advanced Research in Biotechnology (CARB), Parkville, Maryland, USA (Host: Dr. T. Poulos). "Protein crystallography and the design of new sleeping sickness drugs."
126. March 24, 1988 - Dept. of Chemistry, MIT, Cambridge, USA (Host: Dr. G. Petsko). "Structure and evolution of hemocyanins."
127. March 24, 1988 - Dept. of Chemistry, MIT, Cambridge, USA (Host: Dr. G. Petsko). "Protein crystallography and the design of new sleeping sickness drugs."
128. March 25, 1988 - Howard Hughes Medical Institute, Harvard University, Boston, USA (Host: Dr. D. Wiley). "Protein Crystallography in Groningen."
129. April 14, 1988 - 626th Meeting of the Biochemical Society, Sheffield, UK. "Structure and evolution of hemocyanins."
130. April 22, 1988 - Colloquium on Computer Simulations in Protein Engineering and Drug Design, Amsterdam. "Molecular dynamics refinement of thermitase:eglin complexes."
131. May 17, 1988 - 2nd Belgian Organic Synthesis Symposium (BOSS-2), Ghent, Belgium. "Three-dimensional protein structures as basis for the design of new African sleeping sickness drugs."
132. June 20, 1988 - WHO Meeting on "New Strategies for Drug Discovery and Development in Tropical Medicine", Geneva, Switzerland. "Protein Crystallography and Drug Design."
133. July 4, 1988 - 7th International Symposium on Radiopharmaceutical Chemistry, Groningen, The Netherlands. "Protein Crystallography, Molecular Modelling and Rational Drug Design."
134. August 25, 1988 - Summer Congress Royal Dutch Chemical Society, Delft, The Netherlands. "On the intelligence of enzymes."
135. September 12, 1988 - GBF Workshop Advances in Protein Design, Braunschweig, West-Germany. "New developments in protein crystallography."
136. September 27, 1988 - KNAW Academy Workshop on Biogenesis of Peroxisomes, Amsterdam. "Glycosomes, protein crystallography and rational drug design."
137. October 7, 1988 - Bayer Centenary Symposium on "Drug Research and Drug Development in the 21st Century - Science and Ethics", Boppard, West-Germany. "Protein crystallography and Drug Design."
138. November 18, 1988 - Symposium 25 years Commission Biochemistry and Biophysics. Royal Dutch Academy of Sciences, Amsterdam, The Netherlands. "Past, present and future challenges in protein crystallograp-hy."
139. November 25, 1988 - Catholic University of Leuven - Department of Analytical Chemistry and Medical Physical chemistry (Host: Prof. C. de Ranter). "Protein crystallography, protein engineering and the design of new pharmaceuticals."

1989
140. January 10, 1989 - Philips Physical Research Laboratories, Eindhoven, The Netherlands. General Symposium Lecture. "Protein crystallography and protein engineering."
141. January 17, 1989 - Annual Meeting Commission Biochemistry and Biophysics, Royal Academy of Sciences, Amsterdam, The Netherlands. "Bioinformatics."
142. January 27, 1989 - Workshop on Molecular Dynamics Refinement, Daresbury, UK. "Molecular dynamics and refinement of protein crystal structures."
143. April 21, 1989 - International Symposium on chemical and Biochemical Problems in Molecular Recognition, Exeter, UK. "Protein crystallography, computer graphics and sleeping sickness."
144. April 28, 1989 - Symposium New developments in human, infectious diseases, Antwerp, Belgium. "New developments in the design of anti-protozoal drugs."
145. July 5, 1989 - Gordon Conference on Enzymes, Coenzymes and Metabolic Pathways, Kimball Union Academy, New Hampshire, USA. "Structure of Methylamine Dehydrogenase, a Quinoprotein."
146. July 10, 1989 - Department of Chemistry, University of Colorado, Boulder, USA. "New Developments in Protein Crystallography."
147. July 12, 1989 - Department of Chemistry, University of Colorado, Boulder, USA. "Structure of Methylamine dehydrogenase, a Quinoprotein."
148. July 14, 1989 - Department of Chemistry, University of Colorado, Boulder, USA. "Protein Crystallography, Molecular Modelling and the design of new sleeping sickness drugs."
149. July 21, 1989 - School of Medicine, University of Washington, Seattle, USA. "Protein Crystallography and Molecular Modelling: towards new Sleeping Sickness Drugs."
150. July 27, 1989 - International Symposium on Invertebrate Dioxygen Carriers, Leuven, Belgium. "Structure of Arthropod Hemocyanins."
151. August 15, 1989 - International Congress Prospects in Protein Engineering, Haren, The Netherlands. "New Developments in Protein Crystallography."
152. September 4, 1989 - International Summer School Protein and Genetic Engineering, Spetsai, Greece. "Protein Crystallography: Crystallization and Data Collection."
153. September 5, 1989 - International Summer School Protein and Genetic Engineering, Spetsai, Greece. "Protein structure refinement."
154. September 5, 1989 - International Summer School Protein and Genetic Engineering, Spetsai, Greece. "Protein crystallography, computer graphics and design of sleeping sickness drugs."
155. September 7, 1989 - Institute for Molecular Biology and Biotechnology, Iraklion, Greece. "Protein crystallography and computer graphics: towards new sleeping sickness drugs."
156. December 18, 1989 - University of Oregon, Eugene, USA (Host: Prof. B.W. Matthews). "Towards protein-structure based design of new sleeping sickness drugs."

1990
157. January 5, 1990 - Winter Symposium, Royal Dutch Chemical Society, Amsterdam. "Protein crystallography and computer graphics: discovering and designing molecules."
158. April 26, 1990 - London Parasitology Club, UK. "Protein-structure-based design of new sleeping sickness drugs."
159. April 27, 1990 - : University of Oxford, UK, Invited lecture: "Towards Protein-structure-based design of new sleeping sickness drugs."
160. May 9, 1990 - FEBS Workshop in Biophysical and Bioinorganic Chemistry (Organisers T. Brighton and C. Veeger), Louvain-la Neuve, Belgium. "Principles of Protein Crystallography" (2 lectures).
161. May 28, 1990 - : Advanced course on molecular genetics (Organisor H. van Ormondt) Leiden. "Protein structures as a starting point for the design of new drugs and vaccines."
162. May 31, 1990 - Medical Department, University of Toronto, Canada. "Protein crystallography: a starting point for the design of new drugs."
163. July 22, 1990 - XVth International Congress of the International Union of Crystallography, Bordeaux, France (Invited Main Lecture). "Protein Crystallography in Drug Design."
164. August 8, 1990 - IUPAB Satellite Congress, Palmerston North, New Zealand. "Protein-structure-based design of new sleeping sickness drugs - a progress report."
165. August 8, 1990 - Massey University, Palmerston North, New Zealand (Host: Prof. E.N. Baker). "Protein crystallography and the design of pharmaceutically active compounds for treatment of tropical diseases."
166. August 14, 1990 - Fourth Symposium of the Protein Society, San Diego, USA. "Protein crystallography and the design of pharmaceutically active compounds for treatment of tropical diseases."
167. September 11, 1990 - DSM, Geleen (Host: Dr. J. Kamphuis). "Protein Crystallography and Molecular Modelling, Prospects for Protein Engineering and Drug Design."
168. November 8, 1990 - "International Symposium on Crystallography and Molecular Biology", Guaruja-Sao Paulo, Brasil. "Crystallography in Drug Design for Tropical Diseases."
169. November 23, 1990 - Organon Pharmaceutical Company, Oss (Host: Prof. W. Olijve). "Progress in protein structure-based design of sleeping-sickness drugs and the three-dimensional structure of heat-labile enterotoxin."
170. December 14, 1990 - Symposium "Pharmaceutical chemistry in the Netherlands: Past, Present and Future", Weesp: "Surprises in inhibitor-binding by a key enzyme from the sleeping sickness parasite."

1991
171. March 18, 1991 - Organon Pharmaceutical Company, Oss: Symposium on Modern Methods for Drug Design: "Protein crystallography, Molecular Modelling and Design of New Drugs and Vaccines."
172. March 19, 1991 - University of Freiburg, Department of Chemistry (Host: Prof. G. Schulz): "Three-dimensional structure and function of heat labile enterotoxin from E. coli, a close relative of choleratoxin."
173. March 21, 1991 - Meeting of German Microbiological Societies, Freiburg: "Three-dimensional structure of the AB5 complex of the heat-labile enterotoxin from E. coli.
174. April 8, 1991 - Annual Meeting of the SON Discussion Group Crystallography, Lunteren: "Heat-labile enterotoxin from E. coli: an unusual protein with unusual crystals."
175. April 8, 1991 - Dutch Society for Science, The Hague: "Protein crystallography and the development of new drugs."
176. May 15, 1991 - 2nd European Workshop on Crystallography of Biological Macromolecules, Como, Italy: "Protein Crystallography in Drug and Vaccine Design for Tropical Diseases."
177. May 23, 1991 - NMR in Biology, European Scientific Research Conference, Heemskerk: "Strengths and weaknesses of protein crystallography."
178. July 1, 1991 - Symposium in Honour of Sir David Phillips, Oxford: "Protein Crystallography in design and vaccines for tropical diseases."
179. July 9, 1991 - Scripps Research Institute, La Jolla, USA (Host: Dr. P. Wright): "Three-dimensional structure of heat-labile enterotoxin from E. coli, a close relative of cholera toxin."
180. July 12, 1991 - School of Medicine, University of Washington, USA: "Three-dimensional structure of heat-labile enterotoxin from E. coli, a close relative of cholera toxin."
181. September 5, 1991 - Keilin Medal Lecture, Biochemical Society Meeting, Edinburgh, UK: "Protein Crystallography in Discovery and Design of Biomolecules."
182. October 31, 1991 - Institute for Physics and Chemistry, University of Sao Paulo in Sao Carlos, Sao Carlos, Brasil (Host: Prof. G. Oliva): "Crystallography of trypanosomal enzymes and a choleratoxin-related enterotoxin from E. coli: starting points for design of drugs and vaccines for tropical diseases."
183. November 1, 1991 - Faculty of Medicine, University of Sao Paulo in Ribeirao Preto, Robeiro Preto, Brasil: "Crystallography of trypanosomal enzymes and a choleratoxin-related enterotoxin from E. coli: starting points for design of drugs and vaccines for tropical diseases."
184. November 4, 1991 - Institute of Advanced Studies, University of Sao Paulo, Sao Paulo, Brasil: "Crystallography of trypanosomal enzymes and a choleratoxin-related enterotoxin from E. coli: starting points for design of drugs and vaccines for tropical diseases."
185. November 7, 1991 - International meeting on Chagas' disease, Caxambu, Brasil: "Towards protein-structure based design of new therapeutics for treatment of African trypanosomiasis."
186. November 11, 1991 - Institute Oswaldo Cruz, Rio de Janeiro, Brasil (Host: Dr. Carlos Morel): "Crystallography of trypanosomal enzymes and a choleratoxin-related enterotoxin from E. coli: starting points for design of drugs and vaccines for tropical diseases."

1992
187. January 29, 1992 - University of Cambridge, UK (Host: Prof. R. Perham): "Towards the atomic structure of the pyruvate dehydrogenase multienzyme complex."
188. January 30, 1992 - MRC Laboratory of Molecular Biology, Cambridge, UK (Host: Dr. Ph. Evans): "Three-dimensional structure and mode of action of the cholera toxin-related heat-labile enterotoxin from E. coli."
189. February 3, 1992 - McGill University, Montreal, Canada: "The fascinating three-dimensional structure of heat-labile enterotoxin from E. coli, a close relative of cholera toxin."
190. February 21, 1992 - 4th Netherlands Congress on Biotechnology, Amsterdam (Main lecture): "Prospects in Protein Engineering."
191. March 17, 1992 - Working Group on Vaccines, National Organisation for Scientific Research, Lunteren: "Three-dimensional structure of heat-labile enterotoxin from E. coli (LT) as starting point for the development of oral vaccines."
192. April 7, 1992 - Conference on Molecular Recognition, Exeter, UK: "Protein:protein and protein:ligand interactions in bacterial toxins and trypanosome enzymes."
193. June 2, 1992 - IUBMB First Conference on Diseases, Nagoya, Japan: "Computers in Drug Design."
194. June 4, 1992 - Protein Engineering Research Institute, Osaka, Japan (Host: Prof. Kosuke Morikawa): "Structure and dynamics of the pyruvate dehydrogenase multienzyme complex."
195. June 30, 1992 - BASF, Ludwigshafen, Germany (Host: Dr. H.J. Böhm): "Protein crystallography, molecular modelling and African trypanosomiasis."
196. July 14, 1992 - Gordon Conference on Microbial Toxins and pathogenesis, New Hampshire, USA:  "The fascinating three-dimensional structure of heat labile enterotoxin of E. coli, a close relative of choleratoxin."
197. August 11, 1992 - Annual Meeting American Crystallographic Association, Pittsburgh, PA, USA:  "Towards the three-dimensional structure of the pyruvate dehydrogenase multi-enzyme complex."
198. August 28, 1992 - Summer Congress Royal Dutch Chemical Society, Amsterdam, The Netherlands:  "The fascinating protein molecules."
199. September 14, 1992 - Biozentrum, Basel, Switzerland (Host: Prof. J.N. Jansonius):  "Towards the three-dimensional structure of the pyruvate dehydrogenase multi-enzyme complex."
200. September 15, 1992 - International Symposium on Medicinal Chemistry, Basel, Switzerland:  "Protein crystallography, molecular modelling and drug design."
201. September 26, 1992 - Science Symposium, Faculty Natural Sciences and Mathematics, University of Groningen, Groningen, The Netherlands:  "Proteins - three-dimensional structures and design."
202. December 10, 1992 - Science in Medicine Lecture, School of Medicine, University of Washington, Seattle, Washington, USA:  "Exploiting three-dimensional protein structure in New Strategies for Drug and Vaccine Design."

1993
203. February 15, 1993 - Wellcome Foundation's Frontier Conference on Choleratoxin and Related Enterotoxins:  from Disease to Molecular Structure, Broadway, UK:  "Three-dimensional structures of heat labile enterotoxin, a close relative of choleratoxin."
204. March 29, 1993 - University of Houston, Houston, TX:  "Towards the Three-dimensional Structure of the Pyruvate Dehydrogenase Multi-Enzyme Complex:  An Example of Beautiful and Dynamic Protein Architecture."
205. March 31, 1993 -  Texas A&M University, College Station, TX: "Choleratoxin and the Pyruvate Dehydrogenase Complex:  Three-dimensional Structures of Intriguing Multi-Protein Systems."
206. April 1, 1993 - University of Texas, Austin, TX:  "Towards the Three-dimensional Structure of Pyruvate Dehydrogenase Multi-Enzyme Complex:   An Example of Beautiful and Dynamic Protein Architecture."
207. April 1, 1993 - HHMI Research Laboratories, University of Texas-Southwestern Medical Center at Dallas, Dallas, TX:  "Towards the Atomic Structure of the Pyruvate Dehydrogenase Multi-Enzyme Complex."
208. April 14, 1993 -  Upjohn Corporation, Kalamazoo, MI:  "Protein crystallography and tropical diseases:  Receptor binding by choleratoxin, and drug design for treatment of sleeping sickness."
209. April 15, 1993 - Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, NC:  "Towards the Atomic Structure of the Pyruvate Dehydrogenase Multi-Enzyme Complex."
210. April 16, 1993 - Duke University, Durham, NC:  "Fascinating Multifunctional Proteins:  The Pyruvate Dehydrogenase Multi Enzyme Complex and Heat Labile Enterotoxin, a Close Relative of Choleratoxin."
211. May 11, 1993 - EMBL Conference, Heidelberg, Germany:  "Crystal Structure of E. coli Heat-Labile Enterotoxin and of the Choleratoxin B Pentamer in Complex with Its Oligosaccharide Receptor."
212. June 1, 1993 - ICOS Corporation, Seattle, WA, USA:  "Protein Crystallography and Molecular Modeling:  Cholera Toxin and Sleeping Sickness Parasite Enzymes."
213. June 8, 1993 - Sten Gustafsson Symposium on Macromolecular Structure and Drug Design, ASTRA Company, Stockholm, Sweden:  "Receptor recognition by choleratoxin and design of selective inhibitors of trypanosomal enzymes."
214. August 26, 1993 - XVI Congress and General Assembly of the International Union of Crystallography, Beijing, China:  "Towards the Atomic Structure of 2-Oxo Acid Dehydrogenase Multi-Enzyme Complexes."
215. August 26, 1993 - XVI Congress and General Assembly of the International Union of Crystallography, Beijing, China:  "Three-Dimensional Structure of Choleratoxin's B Pentamer in Complex with Its Pentasaccharide Receptor."
216. October 7, 1993 - Biochemistry/Biophysics Seminar, Washington State University, Pullman, WA:  "Protein Crystallography and Molecular Modeling Studies of Choleratoxin and Glycolytic Enzymes of the Sleeping Sickness Parasite:  Structure-Based Design of Selective Inhibitors."
217. November 6, 1993 - Workshop on Innovative Concepts in Drug Design, Fred Hutchinson Cancer Research Center, Seattle, WA:  "Multi-target Protein Structure-Based Drug Design:  Developing New Inhibitors of Trypanosomal Enzymes and of Cholera and Related Toxins."
218. November 12, 1993 -  National Institutes of Health, Bethesda, MD (Host:  Dr. David Davies): "Exploring Three-dimensional Structures of Trypanosomal Enzymes and Cholera Toxin for the Design of Drugs and Vaccines."
219. November 18, 1993 - University of Wageningen, Wageningen, The Netherlands (Host:  Dr. A. de Kok): "Exploring Three-dimensional Structures of Trypanosomal Enzymes and Cholera Toxin for the Design of Drugs and Vaccines."
220. December 2, 1993 -   NIH - 29th U.S.-Japan Joint Conference on Cholera and related Diarrheal Diseases, Asilomar Conference Center, Monterey, CA: "Three-dimensional Structures of Heat Labile Enterotoxin from E. coli and the Cholera Toxin B-Pentamer in Complex with Ganglioside Receptor Saccharides and Engineered for Vaccine Design."

1994
221. February 6, 1994 - University of California, Berkeley, Structural Biology Seminar.  "Intelligent multi-protein systems:  the pyruvate dehydrogenase multi-enzyme complex and cholera toxin."
222. March 11, 1994 - University of Washington, Seattle, WA, Department of Chemistry.  "Protein Crystallography, Molecular Modeling and Infectious Diseases."
223. March 25, 1994 - University of Arizona, Tucson, AZ, Biochemistry Department (Host:  Dr. William Montfort).  "Structure and Function of Complex, Intelligent Proteins: Cholera Toxin & Pyruvate Dehydrogenase Multienzyme Complex."
224. April 24, 1994 -   Structure-Based Drug Design Workshop, Panama City Beach, FL:  "Exploring Three-Dimensional structures of Trypanosomal Enzymes and Bacterial Toxins for Design of Multiple Multifunctional Drugs."
225. September 23, 1994 - Meeting to Honor Max Perutz - Protein Crystallography and Medicine, London, England: "Protein Crystallography and Infectious Diseases."
226. October 25, 1994 - Harvard Medical School, Dept. of Microbiology, Boston, MA: "Protein Crystallography and Infectious Diseases: Cholera toxin and Sleeping sickness."

1995
227. January 7, 1995 - Making the Most of Your Model, Daresbury Laboratory, Cheshire, United Kingdom: "From Structures Via Models to Understanding and New Problems."
228. January 10, 1995 - Utrecht University, Utrecht, The Netherlands (Host: Dr. Piet Gros): "Crystallography and Medicine:  Three Dimensional Structures of the Cholera Toxin Family."
229. January 11, 1995 - Netherlands Cancer Institute, Amsterdam, The Netherlands (Host: Dr. Titia Sixma): "Crystallography and Medicine: Human Protective Protein and Genetic Disease, Diphtheria Toxin Repressor, and Infectious Diseases."
230. February 22, 1995 - Departments of Biochemistry at the University of Minnesota, Minneapolis and St. Paul, MN: "Structure and function of the diphtheria toxin repressor and the cholera toxin family."
231. February 23, 1995 - Dept. of Microbiology, Uniformed Services University of Health Sciences, Bethesda, MD  (Host:  Dr. Randall Holmes): "Structure and function of the diphtheria toxin repressor and the cholera toxin family."
232. February 24, 1995 - CARB, Rockville, MD (Host: Dr. Osnat Herzberg): "Structure and function of the diphtheria toxin repressor and the cholera toxin family."
233. February 27, 1995 - HHMI Scientific Meeting - Infection, Pathogens, and Immunity, Chevy Chase, MD: "Structure and function of the diphtheria toxin repressor and the cholera toxin family."
234. May 25, 1995 - University of California, San Francisco (Host:  Dr. Bob Stroud): "The Fascinating and Dynamic Pyruvate Dehydrogenase Multi-enzyme Complex. "
235. May 26, 1995 -  ASBMB/DBC-ACS Satellite Meeting: Computers and Structure-Based Drug Design, San Francisco, CA:  "Computers and Structure-Based Drug Design"
236. June 29, 1995 -  1995 Gordon Conference, Colby Sawyer College, NH:  "Protein Crystallography and Infectious Diseases."
237. July 11, 1995 - 1995 Protein Society Meeting, Boston, MA:  "Structural investigations of the pyruvate dehydrogenase multi-enzyme complex."
238. August 20, 1995 - XIIIth International Symposium on Glycoconjugates, Seattle, WA (Opening Lecture):  "Carbohydrate receptor recognition by cholera and related bacterial toxins."
239. September 7-8, 1995 - Parke-Davis Pharmaceutical Research, Ann Arbor, MI: "Crystallographic and Protein Engineering Studies of the Cholera Toxin Family."
240. September 25, 1995 - 21st EMBO Annual Symposium 1995, Structure and function of proteins:  "Crystallographic and Protein Engineering Studies of the Cholera Toxin Family."
241. November 17, 1995 - Pinkham Lectureship, Swedish Medical Center, Seattle, WA (Host:  Dr. Lee Norman):  "Crystallographic and Protein Engineering Studies of Cholera Toxin Family."
242. December 1, 1995 - St. Jude's Hospital, Memphis, TN (Host:  Dr. Sandra d'Azzo): "Investigating the secrets of the cholera toxin family by crystallographic and protein engineering techniques."
243. December 12, 1995 - Diabetes Endocrinology Research Center Seminar Series, University of Washington, Seattle, WA (Host:  Dr. Denis Baskin):  "The complex and dynamic world of the pyruvate dehydrogenase multienzyme complex, as unravelled by protein crystallography."
244. December 14, 1995 - Biomembrane Institute, Seattle, WA (Host Dr. Hakomori):  "Investigating the secrets of the cholera toxin family by crystallographic and protein engineering techniques."

1996
245. January 11, 1996 - Instituto de Fisiologia Celular, Universidad Nacional Aut\noma de Mexico, Mexico City (Hosts:  Dr. Armando Gomez-Puyou & Dr. Ruy Pérez-Montfort):  "Crystallization and Protein Engineering Studies of the Cholera Toxin Family and the Immunodominant Heat Shock Protein GroES from Mycobacterium leprae."
246. February 13, 1996 - Research Seminar in Pathobiology, University of Washington (Host:  Jean Feagin):  "Crystallization and Protein Engineering Studies of the Cholera Toxin Family and the Immunodominant Heat Shock Protein GroES from Mycobacterium leprae."
247. February 21, 1996 - Dept. of Microbiology & Immunology, University of British Columbia, Vancouver, B.C. (Host:  J.T. Beatty):  "Protein crystallography and tropical diseases:  cholera toxin and chaperonin GroES from Mycobacterium leprae."
248. March 18, 1996 - HHMI Scientific Meeting - The Structural Analysis of Protein-Protein and Protein-Nucleic Acid Interactions, Chevy Chase, MD: "Protein-Protein Interactions in Chaperonin-10 of Mycobacterium leprae and in the Pyruvate Dehydrogenase Multi-enzyme Complex."
249. March 21, 1996 - University of Illinois Biophysics, Champaign, IL (Host: Dr. Linda Dow): "Intriguing ring-forming proteins: the cholera toxin family and chaperonin-10 from Mycobacterium leprae."
250. April 12, 1996 - Protein Engineering Network Centres of Excellence (PENCE) lecture series, University of Alberta, Edmonton, Alberta, Canada (Host:  Dr. David Bundle):  "Crystal structures and functioning of two intriguing proteins: mycobacterial chaperonin-10 and cholera toxin."
251. May 6, 1996 - Netherlands Cancer Institute, Amsterdam, The Netherlands (Host: Dr. Titia Sixma):  "Intriguing ring-forming proteins: chaperonin-10 from Mycobacterium leprae and the B-pentamer of cholera toxin - implications for structure based drug design."
252. May 8, 1996 - Invited Professorship, ICP, Brussels, Belgium (Host: Dr. Fred Opperdoes):
    Lecture 1: The seven levels of protein structure.
    Lecture 2: Principles of protein crystallography
253. May 9, 1996 - Invited Professorship, ICP, Brussels, Belgium (Host: Dr. Fred Opperdoes):
    Lecture 1: Principles of protein structure-based drug design
    Lecture 2: Computational methods in structure-based drug design
    Lecture 3: Cholera toxin as target for structure-based drug design
    Lecture 4: Trypanosomal Glycosomal enzymes and structure-based drug design
    Lecture 5: Structure based drug design and HIV protease
    Lecture 6: Drug resistance
254. May 12, 1996 -  Experimental & Computational Approaches in Structure Based Drug Design, International School of Crystallography, Erice, Italy (Organizer:  Dr. Penelope Codding):  "Protein Crystallography & Drug Design."
255. May 18, 1996 - Experimental & Computational Approaches in Structure Based Drug Design, International School of Crystallography, Erice, Italy (Organizer:  Dr. Penelope Codding):  "Structural investigations of the cholera toxin family and trypanosomal glycolytic enzymes for the structure-based design of inhibitors."
256. June 23, 1996 - 4th Northwest Crystallography Workshop, Eugene, OR (Organizer: Dr. Brian Matthews):  "Protein Crystallography: Past, Present, and Future" (Keynote Lecture).
257. August 9, 1996 - International Union of Crystallography (IUCr) XVII Congress, Seattle, WA:  "Receptor recognition, protein carbohydrate interactions and a search for receptor antagonists of the cholera toxin family."
258. October 25, 1996 - Oregon Health Sciences University (Host: Dr. Richard Brennan): "Structure Based Inhibitor Design:  The Cholera Toxin Family and Glycolysis in Trypanosomes."
259. November 19, 1996 - 2nd International Conference on Life Science and Biotechnology, Harima Science Garden City, Japan:  "Synchrotron Radiation for Protein Crystallography in Structure-Based Drug Design."

1997
260. January 6, 1997 - Seattle Biomedical Research Institute, Seattle, WA  (Hosts:  Drs. J. Cangelosi & T. White):  "Protein Crystallography, Tropical Diseases and Structure-Based Drug Design."
261. January 15, 1997 - Northwestern University, Chicago IL (Host  Dr. Brian Soichet):  "Structure Based Inhibitor Design:  The Cholera Toxin Family and Glycolysis in Trypanosomes. "
262. February 7, 1997 - Oregon State University, Corvallis OR (Host:  Graduate Students):  "Structure Based Inhibitor Design:  The Cholera Toxin Family and Glycolysis in Trypanosomes. "
263. February 21, 1997 - Univ. of Colorado Health Sciences Ctr. (Host: Dr. Randall Holmes):  "Crystallographic investigations of cholera toxin and the diphtheria toxin repressor - structure, function and design of antagonists."
264. March 27, 1997 - Seattle Protozoology Conference (Organizer:  Dr. Jean Feagin):  "The crystal structure of phosphoglycerate kinase from Trypanosoma brucei: new insight into the mechanism and opportunities for drug design."
265 April 12-16, 1997 - Protein Society Meeting, Cambridge University, Cambridge, England:  "Crystallographic Investigations of the Pyruvate Dehydrogenase Multienzyme Complex:  The High-Symmetry Core and the Principle of Quasi-Equivalence."
266. May 1, 1997 - Dept. of Medicinal Chemistry, Univ. of Washington (Hosts:  Drs. Kenneth Thummel & Valerie Daggett):  "Protein Crystallography, Structure Based Drug Design and Third World Diseases."
267. May 18-21, 1997 - HHMI Scientific Meeting - Infection and Immunity, Chevy Chase, MD:  "Structure-based design of drugs for infectious tropical diseases."
268. June 12, 1997 -  The Alfred Benzon Symposium No. 42 - Rational Molecular Design in Drug Research, Copenhagen, Denmark: "Protein crystallography, Tropical Diseases and Drug Design."
269. June 16, 1997 - University of Groningen Protein Crystallography Lab, The Netherlands (Host:  Dr. Bauke Dijkstra): "Towards the design of drugs, plugs, vaccines and adjuvants on the basis of the crystal structures of the cholera toxin family."
270. June 22, 1997 - Basel Biozentrum (Host: Prof. J.N. Jansonius): "Three-dimensional architecture of the cholera toxin family: A basis for the design of vaccines, receptor inhibitors and assembly antagonists."
271. June 30, 1997 - Eighth European Workshop conference on Bacterial Protein Toxins, Kloster Banz, Staffelstein, Germany:  "Three-dimensional architecture of the cholera toxin family: A basis for the design of vaccines, receptor inhibitors and assembly antagonists."
272. July 19, 1997 - 1997 ACA Meeting, St. Louis, MO: "Structure-Based Drug Design - A meeting place of Angstroms, Kilocals, Insight, Serendipity and Creativity."
273. July 23, 1997 - 1997 ACA Meeting, St. Louis, MO: "Future trends and Hot Topics"
274. July 24, 1997 - 1997 ACA Meeting, St. Louis, MO: "Crystallographic Investigations of the Pyruvate Dehydrogenase Multienzyme Complex:  High-Symmetry Cores and the Principal of Quasi-Equivalence."
275. September 25, 1997 - Molecular Parasitology Meeting VIII, Woods Hole, MA:  "Protein crystallography and molecular modeling for the design of inhibitors of key proteins in trypanosomiasis, leishmania, and malaria."
276. October 31, 1997 - Smith Kline Beecham, King of Prussia, PA (Host: Dr. Xiayang Qiu):"Protein crystallography and structure based design of drugs and plugs for trypanosomiasis, malaria and cholera."
277. November 3, 1997 - PennState College of Medicine, Hershey, PA (Host: Dr. Cara Schengrund):  "Protein Crystallography, Protein Engineering and Inhibitor Design Studies of Cholera and Related Toxins."

1998
278. March 25, 1998 - Bristol Myers Squibb, Wallingford, CT (Hosts: Drs. David Langley and Howard Einspahr):  "Protein Crystallography and Molecular Modeling for the Design of Drugs for Tropical diseases and the Structure Determination of Human Topoisomerase I."
279. March 26, 1998 - Boston Structural Biology Seminar, Harvard Medical School (Host:  Dr. Tom H. Ellenberger):  "Crystal Structure of Human Topoisomerase I in Covalent and Non-Covalent Complexes with DNA."
280. April 22, 1998 - St. Jude Children's Research Hospital, Memphis, TN (Host: Dr. Stephen W. White): "A Crystal Structure of Human Topoisomerase I in Covalent and Non-covalent Complex with DNA Leading to a Model for the Binding Mode of the Anti-Cancer Drug Camptothecin."
281. April 23, 1998 - St. Jude Children's Research Hospital, Memphis, TN (Host: Dr. Stephen W. White): "Protein Crystallography and Molecular Modeling for Designing Inhibitors Targeting Cholera Toxin and Other Tropical Pathogens."
282. May 28, 1998 - Scripps Research Institute, La Jolla, CA (Host: Dr. Ian Wilson): Structure and Chemistry Seminar, "Macromolecular Assemblies:  The Pyruvate Dehydrogenase Complex."
283. May 29, 1998 - Scripps Research Institute, La Jolla, CA (Host: Dr. Ian Wilson): Graduate Course Lecture, "Human Topoisomerase I and Cholera Toxin as a Platform for Design of Drugs, Plugs and Vaccines."
284. June 4, 1998 - IOCD Workshop on Medicinal Chemistry, Granada, Spain (Host:  Dr. Fred Opperdoes):  "Drug Design Based Upon the X-ray Structures of Glycolytic Enzymes in the Trypanosome."
285. July 22, 1998 - American Crystallography Association 1998 Annual Meeting, Arlington, VA: "Protein Crystallography in Drug Design:  Tropical Diseases and Human Topoisomerase I."
286. July 27, 1998 - XIIIth International Congress of Pharmacology, Munchen, Germany.  "Structure -based Design of Inhibitors of Key Proteins in Trypanosoma brucei and Plasmodium falciparum."
287. July 29, 1998 - XIIIth International Congress of Pharmacology, Munchen, Germany.  Invited Lecture, "Structure-based Design of Multiple Drugs Targeting Entirely Different Areas of Cholera Toxin and E. coli Heat-labile Enterotoxin."
288. July 31, 1998 - Netherlands Cancer Institute, Amsterdam (Host:  Dr. Titia K. Sixma):  "The Crystal Structure of Covalent and Noncovalent Complexes of Human Topoisomerase I in Complex with DNA, Leading to a Model for the Binding Mode of the Anti-Cancer Drug Camptothecin."
289. November 4, 1998 - Computational Biology Seminar Series, University of Washington.  "Challenges in Fundamental and Goal-Oriented Protein Crystallography:  About Platonic Macromolecular Assemblies and Structure-Based Drug Design."
290. November 11, 1998 - Center for Computational Sciences, University of Kentucky (Host:  Dr. Danzhou Yang)  "Protein Crystallography in Drug Design:  Tropical Diseases and Human Topoisomerase I."
291.  December 14, 1998 - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute (Host:  Dr. James B. Ames)  "The structures of all essential components of the pyruvate dehydrogenase multi-enzyme complex family, including a successful quaternary protein structure prediction."

1999
292. January 22, 1999 - State University of New York, Buffalo (Host:  Dr. Philip T. LoVerde)  "Protein crystallography in structure-based drug design for tropical diseases with speacial emphasis on trypanosomes and cholera."
293.  March 12, 1999 - University of California, San Francisco (Host:  Dr. C.C. Wang)  "Protein crystallography in design and understanding of drugs."
294.  April 9, 1999 - Molecular Approaches Toward Understanding Disease Symposium, Molecular and Cellular Biology Program of the University of Washington.  "Protein crystallography and the design of therapeutics for global diseases."
295.  June 7, 1999 - University of Alberta, Edmonton (Host:  Dr. Catherine McPhalen)  "Structure, symmetry, dynamics and functioning of the pyruvate dehydrogenase multi-enzyme complex."
296.  June 25, 1999 - 1st EMSL Workshop on Structural Genomics, Environmental Molecular Sciences Laboratory, Richland, Washington (Organizer:  Dr. Michael A. Kennedy)  "Structural genomics and the development of new pharmaceuticals for parasitic diseases."
297.  June 28, 1999 - University of Medicine & Dentistry of New Jersey, Robert Wood Johnson Medical School (Host:  Dr. Leroy Liu)  "Protein crystallography in design and understanding of drugs.  About cholera, sleeping sickness and topoisomerase I."
298.  June 29, 1999 - Schering Plough Pharmaceuticals, Kenilworth, New Jersey (Host:  Dr. Patricia Weber)  "Protein crystallography in design and understanding of drugs.  About cholera, sleeping sickness and topoisomerase I."
299.  August 7, 1999 - XVIIIth Congress of the International Union of Crystallographers, Glasgow, Scotland.  "Human topoisomerases I:  Structure, action, inhibition and cancer."
300.  August 27, 1999 - Fifth International Congress of Comparative Physiology and Biochemistry, Calgary, Alberta, Canada.  (Host:  Dr. Hans J. Vogel)  "Structural insights into the function of DNA topoisomerases."
301.  September 27-28, 1999 - Conference in honor of Herman C. Berendsen, Groningen Biomolecular Sciences and Biotechnology Institute, Groningen, The Netherlands (Host:  Dr. Wilfred F. Van Gunsteren)  "Dynamic Biomacromolecules."
302.  September 30, 1999 - Netherlands Cancer Institute (Host:  Titia Sixma)  "Protein Crystallography, Combinatorial Chemistry and Drug Design"
303.  November 10, 1999 - International Institute of Cellular and Molecular Pathology, Brussels, Belgium (Host:  Dr. Paul A.M. Michels)  "Protein crystallography and structure-based drug design for trypanosomatids - A story of Glycosomal GPDH, ALDO and GAPDH."
304.  November 13, 1999 - KNMG Congres, Royal Dutch Society of Medicine, Den Haag, The Netherlands.  "Basiswetenschappen en geneeskunde."
305.  December 9, 1999 - Oklahoma Medical Research Foundation, Oklahoma City (Host:  Dr. Allen Edmundson)  "Protein crystallography and drug design - Cholera, sleeping sickness, cancer."

2000
306.  February 2-5, 2000 - Molecular Approaches to Malaria 2000 Conference, Lorne, Victoria, Australia (Organizer:  Dr. Alan F. Cowman)  "Structure -based drug design for tropical diseases."
307.  February 7, 2000 - Lorne Protein Conference, Lorne, Victoria, Australia (Organizer:  Dr. Robin Anders)  "Crystallographic studies on dynamic proteins:  human topoisomerase I and the pyruvate dehydrogenase multi-enzyme complex."
308.  February 11,2000 - University of New South Wales, Sydney, Australia (Host:  Dr. Tom Stewart)  "Structure and function of two dynamic proteins:  topoisomerase I and the pyruvate dehydrogenase multienzyme complex."
309.  February 28, 2000 - Medical Scientist Lecture Series, 1999-2000, University of California, Irvine (Host:  M.D./Ph.D. Students Association)  "Protein crystallography and drug design:  cholera, trypanosomiasis and cancer."
310.  March 26-29, 2000 - EMBL Millenium Symposium in Structural Biology, Heidelberg, Germany; Evening Lecture (Organizers:  Drs. Andreas Hoenger, Matti Saraste, Irmi Sinning, Dietrich Suck)  "On the sophistication of DNA binding proteins:  iron-dependent repressors and human topoisomerase I."
311.  April 25, 2000 - Tri-Institutional Structural Biology Seminar Series; Rockefeller University, Sloan-Kettering Institute and The Weill Medical College of Cornell University, New York (Host:  Dr. Hao Wu)  "On the sophistication of DNA binding proteins:  Iron-dependent repressors and human topoisomerase I"
312.  May 25-June 4, 2000 - 30th Course:  Crystallography of Molecular Biology, International School of Crystallography, Erice, Italy (Organizers:  Drs. Louise Johnson and Dave Stuart)  "Dynamic multienzyme complexes with highly symmetric cores"
313.  June 30, 2000 - University of Pennsylvania, Philadelphia (Host:  Dr. David Roos)  "The complex pyruvate dehydrogenase multi-enzyme family - seen from an architectural and malaria point of view."
314.  July 26, 2000 - American Crystallographic Association Meeting, Minneapolis-St. Paul, MN - HHMI Symposium in honor of Dr. Purnell Chopin.  "Protein Crystallography and  Tropical Diseases."
315.  September 9, 2000 - North Pacific Society of Internal Medicine, Gleneden Beach, OR - "Genetics and Molecular Structure: New Understanding, Future Applications."
316.  September 18, 2000 - Program in Structural Biology, Frederick, MD - Symposium on Structural Biology (Organizer: Dr. Alex Wlodawer).  "The pyruvate dehydrogenase family: dynamic multienzyme complexes with highly symmetric cores."
317. October 1-4, 2000 - Howard Hughes Medical Institute Scientific Meeting: Infection and Immunity, Chevy Chase, MD - "Monovalent and Pentavalent Receptor Antagonists of Cholera Toxin."
318. October 26, 2000 - Department of Pathobiology Autumn 2000 Seminar Series, University of Washington, Seattle (Host:  Dr. David Sherman)  "Structural Biology of Mycobacterium tuberculosis:  Proteins for Drug Design."
319. November 7, 2000 - Lerner Research Institute 2000-2001 Seminar Series, The Cleveland Clinic Foundation, Cleveland, OH (Host: Dr. Vivien Yee)  "Investigating the structure and DNA-binding modes of iron-dependent repressors and human topoisomerase I, the target of camptothecins.

2001
320.  February 2, 2001 - Tularik, Inc., South San Francisco, CA (Host:  Dr. Heather K. Webb)  "Structure-guided design of monovalent and pentavalent receptor antagonists of cholera toxin."
321.  February 23, 2001 - Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands (Host:  Dr. Rob Kaptein)  "Structural biology and structure-guided design of therapeutics."
322.  March 3, 2001 - Structural Biology and Bioinformatics Conference, University of North Carolina, Chapel Hill, School of Medicine, Chapel Hill, NC (Host:  Dr. Jan Hermans)  "Structure-guided design of monovalent and pentavalent receptor antagonists of cholera toxin."
323.  April 5, 2001 - Macromolecular Machines, The Annual Symposium of the Burnham Institute, La Jolla, CA (Organizers: Drs. Robert Liddington and Dorit Hanein)  "The Pyruvate Dehydrogenase Multi-Enzyme Complex Family."
324.  April 6, 2001 - Structural GenomiX, Inc., San Diego, CA (Hosts: Drs. Jörg Hendle and Wendy Sanderson)  "Structure-guided design of monovalent and pentavalent receptor antagonists of cholera toxin."
325.  June 7, 2001 - University of California at Davis (Host: Graduate Students of the Section of Molecular and Cellular Biology)  "Structure-guided design of monovalent and pentavalent receptor antagonists of cholera toxin."
326.  June 20, 2001 - Bioorganic Chemistry Gordon Conference, Andover, NH - "Protein crystallography and drug design:  Surprises in small ligands and power of mega-ligands."
327.  September 20, 2001 - Nijmegen Center for Molecular Life Sciences Symposium - The Omics Revolution in Molecular Life Sciences, Nijmegen, The Netherlands (Host: Prof. dr. Jan Joep de Pont)  "Structural genomics, structure-based drug design and medicine."
328.  October 24, 2001 - 15th Annual CABM Symposium - Structural Genomics in Pharmaceutical Design, Princeton, NJ (Host: Dr. Eddy Arnold)  "Protein structures from tropical parasites: A drug design perspective."
329.  November 10, 2001 - University of Colorado Molecular Biology Program Retreat, Estes Park, CO (Host: Dr. Randall Holmes)  "Protein crystallography, infectious diseases and drug design."
330.  December 3, 2001 - University of Georgia College of Pharmacy Seminar, Athens, GA (Host: Dr. Cory Momany and Dr. B.C. Wang)  "On structure-based drug design and structural genomics for infectious diseases."
 

2002

331. January 29, 2002 - Johns Hopkins Malaria Research Institute Conference, Baltimore, MD (Host: Dr. David Sullivan) "Structure-based inhibitor design of tropical pathogen proteins." (Keynote Lecture)
332. January 30, 2002 - Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine (Host: Dr. Cynthia Wolberger and Dr. Mario Amzel) "Protein crystallography in structure-based drug design for infectious diseases."
333. March 7, 2002 - Keystone Conference Drugs Against Tropical Protozoan Parasites: Targets Selection, Structural Biology and Rational Medicinal Chemistry, Keystone, CO (Host: Dr. Michael Gelb and Dr. Wim Hol, co-organizers) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases."
334. March 10, 2002 - Harvard-MIT Conference on Infectious Disease, Boston, MA (Host: Harvard Hippocratic Society, Dr. Parin Patel) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases."
335. April 9, 2002 - Einstein College of Medicine - Yeshiva University, Bronx, NY (Host: Dr. Mark E. Girvin) "Medicinal Crystallography and Structural Genomics for Tropical Diseases."
336. April 10, 2002 - American Red Cross, Rockville, MD (Host: Dr. Maria Sandkvist) "Protein Crystallography in Drug Design for Protozoal and Bacterial Tropical Diseases."
337. June 4, 2002 - 11th Max Gruber Lecture, Groningen, The Netherlands, (Host: Dr. G. Ab and Dr. W. Konings) "Medicinal protein crystallography and structural genomics for tropical diseases."
338. June 6, 2002 - National Institute for Medical Research, Mill Hill, UK, (Host: Dr. A. Holder and Dr. G.G. Dodson) "Medicinal protein crystallography and structural genomics for tropical diseases."
339. June 7, 2002 - Bridget Ogilvie Lecture, University of Dundee, Scotland, (Host: Dr. Alan Fairlamb) "Medicinal protein crystallography and structural genomics for tropical diseases."
340. July 11, 2002 - Seattle Malaria Interest Group, "Malaria and Structural Genomics of Pathogenic Protozoa (SGPP)"
341. July 25, 2002 - International Summer School, Cargese, France, (Host: Dr. Michel Duguet) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases."
342. August 7, 2002 - XIX Congress and General Assembly of the IUCR - Geneva, Switzerland, "Inhibitor Design And The Cholera Toxin Family - From Water Puzzles To 10 Kd Spiders" (Keynote Lecture)
343. Sept 24, 2002 - HHMI Annual Scientific Meeting, Chevy Chase, MD "Expected and Unexpected Protein Ligand Interactions."
344. October 11, 2002 - International Structural Genomics Organization (ISGO), Berlin, Germany (Organizer: Prof. Udo Heinemann) "Structural Genomics and Medicinal Protein Crystallography for Tropical Diseases"
345. October 25, 2002 - University of Alberta, Canmore, Canada (Host: Dr. Michael James) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"
346. November 15, 2002 - Pfizer Inc. (Host: Dr. Preston Hensley) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"
347. November 26, 2002 - Protein Structure Determination in Industry (PSDI), Buxton, UK (Organizer: Dr. Richard Pauptit, Astrazeneca) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"


2003


348. Feburary 13, 2003 - C.V. Raman Visiting Professorship, India (Host: Professor N. Yathindra) "Harnessing the powers of Biology, Chemistry, Informatics and Physics for combating tropical diseases in the post-genomic era"
349. February 14, 2003 - C.V. Raman Visiting Professorship, India (Host: Professor N. Yathindra) "Protein crystallography and structure based drug design"
350. February 17, 2003 - C.V. Raman Visiting Professorship, India (Host: Professor N. Yathindra) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"
351. February 18, 2003 - Indian Institute of Science, Bangalore, India, (Hosts: Dr. N. Murty and Prof. M. Vijayan ) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"
352. February 19, 2003 - Center for DNA Fingerprinting & Diagnostics, Hyderabad, India (Host: Dr. Shekhar Mande) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"
353. February 21, 2003 - Indian Biophysical Society, Annual Meeting, Roorkee, India, (President: Dr. Rabi Majumdar) The 2nd G.N. Ramachandran Memorial Lecture: "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"
354. February 24, 2003 - Dept of Biophysics, All India Institute of Medical Sciences (AIIMS), Delhi, (Host: Dr. T.P. Singh) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"
355. March 25, 2003 - Keck Center For Microbial Pathogens, University of Washington, Seattle, USA "Medicinal Protein Crystallography and Structural Genomics for Global Diseases"
356. March 31, 2003 - HHMI Annual Scientific Meeting, Chevy Chase, MD "Crystallographic Investigations of Cholera Toxin's Secretion and Activation"
357. May 1, 2003 - Department of Pathobiology, University of Washington, Seattle, USA (Host: Dr. Patrick Duffy) "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases"
358. June 28, 2003 - 11th European Workshop on Bacterial Protein Toxins, Prague, Czech Republic (Organizer: Dr. Peter Sebo) "A dodecade of structure solving, targeting cholera toxin, its family members, partners, and friends."
359. August 6, 2003 - Seattle Malaria Interest Group, "Structural Biology and Structural Genomics of Malaria - Progress and Challenges"
360. August 25, 2003 - 21st European Crystallographic Meeting (ECM21), Durban, South Africa (Host: Dr. Jan Boeyens) "Drug targets in tropical diseases" (Plenary lecture)
361. September 7, 2003 - TB Structural Genomics Consortium Retreat, Santa Fe, USA (Host: Dr. Thomas Terwiliger) "Technology and the Structural Genomics of Pathogenic Protozoa"
362. September 25, 2003 - Danforth Symposium on Microbial Genomics and Structural Genomics, Washington University, St. Louis, USA (Host: Dr. Steve Beverly) "Medicinal Protein Crystallography for Tropical Diseases"
363. November 13, 2003 - NIGMS Protein Structure Initiative Workshop on Target Selection, Bethesda, MD "Target Selection Relevant to Health"


2004

364. April 18, 2004 - Keystone Symposia on Structural Genomics, Snowbird, Utah, "Structural Genomics of Pathogenic Protozoa (SGPP)"
365. May 27, 2004 - Molecular Biophysics Mini-Symposium, Rutgers University, Piscataway, New Jersey, "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases" (Keynote Lecture)
366. May 28, 2004 - Chancellor's Distinguished Lectureship Series, Louisiana State University, Baton Rouge, Louisiana, "Medicinal Protein Crystallography and Structural Genomics for Tropical Diseases" (Keynote Lecture)
367. June 3, 2004 - Structural Proteomics and Protein-Protein Interactions, Centre for Biomedical Genetics (CBG) / Structural Proteomics in Europe (SPINE), Amsterdam, The Netherlands, "Structural Biology and Structural Genomics of Tropical Pathogens"
368. August 16, 2004 - The Protein Society, San Diego, California, "18th Annual Symposium of the Protein Society: Protein Structure, Function and Disease"
369. September 8, 2004 - Seattle Malaria Special Interest Group, Seattle, WA, "Structural Biology and Structural Genomics for Tropical Pathogens, with special emphasis on malaria"
370. September 16, 2004 - TriTryp Genomes Meeting 2004, Seattle Biomedical Research Institute, Seattle, WA "Structural Genomics Of Pathogenic Protozoa (SGPP) Building A Solid Foundation For Treatment And Prevention Of Tropical Parasitic Protozoan Diseases."
371. September 22, 2004 - University of Washington, Joint Genome Science and Biochemistry Retreat, Leavenworth, WA, " Technology and the Future of Structural Biology Research"
372. Oct ober13, 2004 - Mexican Congress of Parasitology, Tlaxcala, Mexico "Structural Biology, Structural Genomics and Structure-Based Drug Design forTropical Diseases."
373. October 18, 2004 - Structural Proteomics in Europe 2004, London, UK "Protein crystallography and structure-based drug design for tropical parasitic diseases."
374. November 17, 2004 - International Conference on Structural Genomics 2004, Washington DC "Structural Genomics of Pathogenic Protozoa (SGPP) building a solid foundation for treatment and prevention of tropical parasitic protozoan diseases."
375. December 16, 2004 - Decode Biostructures, Bainbridge Island, WA "Structural Genomics of Pathogenic Protozoa (SGPP) building a solid foundation for treatment and prevention of tropical parasitic protozoan diseases."


2005


376. April 13, 2005 - University of Colorado, Department of Microbiology, Aurora, CO (Host Dr. Randall Holmes) "Towards Understanding the Complicated Life Style of Cholera Toxin at the Atomic Level"
377. May 15, 2005 - HHMI, Chevy Chase, MD "Structural Biology in the Search for New Treatments of Tropical Diseases"
378. August 15, 2005 - Wyeth Research Structural Biology Symposium, Boston, MA (Host: Dr. Will Somers) "Structural Biology in the Search of New Therapeutics for Tropical Diseases"
379. August 29, 2005 - XXth IUCR Congress of the International Union of Crystallography, Florence, Italy "Molecular Machines and Tropical Pathogens"
380. September 7, 2005 - Seattle Malaria Group, Seattle, WA "Unraveling three-dimensional structures of key cell entry proteins and key enzymes of the malaria parasite"

 


2006

381. February 8, 2006 - Novartis NIBR Seminar Series, Cambridge, MA (Host: Dr. Travis Stams) " Structural Biology in the Search of New Therapeutics for Tropical Diseases"
382. March 22, 2006 - Christian de Duve Institute of Cellular Pathology, Brussels, Belgium (Host: Dr. Paul Michels) " Structural Biology in the Search of New Therapeutics for Tropical Diseases"
383. March 23, 2006 - University of Ghent, Belgium (Host: Dr. Jozef Van Beeumen) "Structural Biology in the Search of New Therapeutics for Tropical Diseases"
***. March 24, 2006 - Formal Thank You on behalf of Honorary Doctorates, University of Ghent, Belgium
384. June 5, 2006 - Conference on Drug Development for the Third World, Trieste, Italy "Many Modes of Drug Action"
385. June 6, 2006 - Conference on Drug Development for the Third World, Trieste, Italy "Structural Biology in Drug Design and The Power of Multivalency"
386. June 7, 2006 - Conference on Drug Development for the Third World, Trieste, Italy "Medical Structural Genomics for Tropical Diseases"
387. June 8, 2006 - Jubileum Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) en 50 Jaar Chemie, Bussum, The Netherlands "Perspektief van een Nederlandse Buitenlander."
388. June 17, 2006 - South West Macromolecular Symposium, The Woodlands, TX "Structural Biology, Molecular Machines and Tropical Diseases" (Keynote Lecture)
389. July 27, 2006 - American Crystallographic Association, Annual Meeting, Oahu, HI. "Molecular Machines, Tropical Pathogens and Difficult Structures"
390. September 6, 2006 - Seattle Malaria Group, Seattle, WA. "Structural Biology of the Invasion Machinery of the Malaria Parasite"
391. November 28, 2006 - Structural Biology in the 21st Century Seminar Series, Hauptmann Woodward Medical Research Institute, Buffalo, NY "Structural Biology in the Search for New Therapeutics for Tropical Diseases"
392. November 29, 2006 - University of Buffalo, Buffalo, NY, Dept of Microbiology Seminar (Host: Dr. Terry Connell) "Structural Biology, Molecular Machines and Tropical Diseases"
393. December 11, 2006 - 50th Annual Meeting StudieGroep Eiwitonderzoek Luntern, NWO, Luntern, The Netherlands (Host: Dr. Rolf Boelens) "Structural Biology, Molecular Machines and Tropical Diseases" (Keynote Lecture)


2007


394. January 17, 2007 - Gordon Research Conference, RNA Editing, Ventura, CA. (Organisers: Dr. Mary O'Connell and Ken Stuart) "Crystallographic and Biochemical Studies of the Editosome from Trypanosoma brucei"
395 March 6, 2007 - Department of Pharmaceutical Sciences Medical University of South Carolina, Charleston SC (Host: Dr. Craig Beeson) "Structural Biology in Support of Design of new Therapeutics for Tropical Diseases especially of Tuberculosis"
396. March 19, 2007 - Frontiers in Medicinal Chemistry, Joint German-Swiss Meeting on Medicinal Chemistry, Freie Universität Berlin, Germany "Structural Biology in the Search for New Therapeutics for Tropical Diseases"
397. March 28, 2007 - Workshop "Merging Chemical and Biological Space" (Organizer: Dr. Gerhard Klebe) Schloss Rauischholzhausen bei Marburg am Lahn, Germany "Structural Biology in the Search for New Therapeutics for Tropical Diseases"
398. April 26, 2007 - Structure and Chemistry Affinity Group Seminar Series (Host: Dr. John Tainer) The Scripps Research Institute, La Jolla, CA "Structural Biology, Molecular Machines and Tropical Diseases"
399. May 10, 2007 - Science in Medicine Lecture Series University of Washington, School of Medicine, Seattle, WA "Structural Biology in the Fight against Tropical Diseases" (Distinguished Scientist Lecturer)
400. August 23, 2007 - 21st Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Ghent, Belgium (Host: Prof. Dr. Edwin Claerebout) "Structural Biology in the Search for New Therapeutics for Protozoal Diseases" (Plenary Lecture)
401. August 24, 2007 - Vlaams Instituut voor Biotechnologie, Ghent, Belgium (Host: Dr. Jos van Beeumen) "Structural Biology in the Search of New Therapeutics for Tropical Diseases"
402. September 3, 2007 - University of Groningen, Groningen, The Netherlands (Host: Dr. Bauke W. Dijkstra) "Structural Biology in the Search of New Therapeutics for Tropical Diseases"
403. September 5, 2007 - Murnau Conference 2007 on Structural Biology of Disease Mechanisms, Murnau, Germany (Organizer: Dr. Dirk W. Heinz) "Structural Biology in the Search of New Therapeutics for Tropical Diseases" (Second Murnau Lecture)
404. September 10, 2007 - ACS Prospective Series Symposium - Advances in Structure-Based Drug Discovery, San Francisco, CA (Host: Dr. Dagmar Ringe) "Structural Biology in Drug Design for Tropical Diseases"
405. October 25, 2007 - Universitair Medisch Centrum Groningen (UMCG), The Netherlands, "Translating Structural Biology into Medical Practice; Bridging the Gap" (First Thomassen à Thuessink Lecture)
406. November 27, 2007 - Second Annual Montreal Structural Biology Meeting, McGill University, Montreal, Canada (Hosts: Dr. Mirek Cygler, Dr. Albert Berghuis) "Structural Biology in the Search for New Therapeutics for Tropical Diseases" (Keynote)
407. November 28, 2007 - Dept. of Biochemistry, McGill University, Montreal, Canada, (Hosts: Dr. Kalle Gehring, Dr. Albert Berghuis) "Structural Biology, Molecular Machines and Tropical Diseases"
408. November 29, 2007 - Dept of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Chicago, IL, (Host: Dr. Alfonso Mondragon) "Structural Biology, Molecular Machines and Tropical Diseases"


2008


409. May 9, 2008 - Seattle Parasitology Conference, Seattle, WA, "Medical Structural Genomics of Pathogenic Protozoa (MSGPP): From Genomes To Compounds Bound To Protozoan Drug Targets In Three Dimensions"
410. May 14, 2008 - Genes and Genomes in the Tropics Course - Malaria and Polymicrobial Interactions, Kampala, Uganda (Organizers: Dr. Matts Wahlgren, Karolinska Institute, Sweden and Dr. Fred Kironde, Makerere University, Kampala, Uganda) "Structure-based Design of Anti-protozoals"
411. May 16, 2008 - Keystone Symposia on Translating New Technologies to Improve Public Health in Africa, Kampala, Uganda (Organizers: Dr. Jim Bennett and Dr. Mamoun Homeida) "Structure-Based Design of Anti-Protozoals"
412. June 3, 2008 - 108th General Meeting - American Microbiology Society (AMS) Boston, MA - Session on Type II Protein Secretion: New Insights into Structure, Function, and Pathogenesis, - Organizers: Maria Sandkvist and Nick Cianciotto: "Towards the architecture of the Type 2 Secretion System"
413. June 4, 2008 - 2008 Annual conference American Crystallographic Association (ACA), Knoxville, TN, Patterson Award Session for B.C. Wang (Organisers: John Rose and Gary Newton) "Molecular machines, tropical diseases and the power of llamas"
414. June 11, 2008 - Royal Swedish Academy of Sciences (KVA) Aminoff Award Symposium for Hans Eklund, Stockholm, Sweden (Organiser: Alwyn Jones) "Structural biology and the complicated lifestyle of two bacterial AB5 toxins."
415. October 16, 2008 - Stanford Synchrotron Radiation Laboratory (SSRL) User Meeting - San Francisco, CA - Scientific Highlights Session "Towards understanding the Type 2 Protein Secretion Machinery".
416. October 31, 2008 - Symposium 25 Years Max Gruber Stichting, University of Groningen, The Netherlands (Organiser: Wil Konings): "Structural Biology for Biology and Medicine"


2009

417. April 14, 2009 - Burnham Institute for Medical Research 2009 Symposium on "Host Pathogenic Interactions", La Jolla, CA, (Organizers: Robert C. Liddington and Alex Strongin): "Towards the architecture of the Type 2 Secretion System"
418. May 14, 2009 - Seattle Parasitology Conference, SBRI, Seattle, WA: "tRNA Synthetases of Pathogenic Protozoa as Targets for Drug Development"
419. June 1 and 2, 2009 - International Center for Theoretical Physics ( ICTP), Trieste, Italy, Conference on "Drug Development for the Third World": "Many Modes of Drug Action"
420. June 2, 2009 - International Center for Theoretical Physics ( ICTP), Trieste, Italy, Conference on "Drug Development for the Third World": "Structural Biology in Drug Design"
421. June 3, 2009 - International Center for Theoretical Physics ( ICTP), Trieste, Italy, Conference on "Drug Development for the Third World": "Targeting the invasion machinery of the malaria parasite"
422. June 4, 2009 - International Center for Theoretical Physics ( ICTP), Trieste, Italy, Conference on "Drug Development for the Third World": "Diarrheal Diseases
and the Power of Multivalency in Drug Design"
423. June 4, 2009 - International Center for Theoretical Physics ( ICTP), Trieste, Italy, Conference on "Drug Development for the Third World": "Modes of Drug Resistance - and what we may able to do about it"
424. June 5, 2009 - International Center for Theoretical Physics ( ICTP), Trieste, Italy, Conference on "Drug Development for the Third World": "Structures of tuberculosis drug targets - and how these might be used for drug design"
425. June 5, 2009 - International Center for Theoretical Physics ( ICTP), Trieste, Italy, Conference on "Drug Development for the Third World": "tRNA Synthetases of Pathogenic Protozoa as Targets for Drug Development"
*** June 9, 2009 - Laudiatio for the Award of the Spinoza Prize to Dr. Michel Ferrari, The Netherlands Organization for Scientific Research (NWO), The Hague, The Netherlands.
426. July 24, 2009 - Gordon Research Conference on “Microbial Adhesion & Signal Transduction”, Salve Regina University, Newport, Rhode Island, USA (Organizers: Michael Starnbach and Alain Filloux): "Towards the architecture of the Type 2 Secretion System"
427. September 18, 2009 - Department of Medical Microbiology, Vrije Universiteit (VU), Amsterdam, The Netherlands (Host: Dr. Wilbert Bitter): "Molecular Machines, Tropical Diseases and the Power of Llamas"
428. September 21, 2009 - Brussels Structural Biology, Vrije Universiteit Brussels (VUB) and Vlaams Institute of Biotechnology (VIB), Brussels, Belgium (Host: Dr. Jan Steyaert): "Molecular Machines, Tropical Diseases and the Power of Llamas"
429. October 1, 2009 - Fall Research Symposium, The Scripps Research Institute, La Jolla, CA, USA (Host: Dr. Shiva Bhowmik): "Molecular Machines, Tropical Diseases and the Power of Llamas"
430. November 6, 2009 – Dept. of Biochemistry and Molecular Biology, Simon Fraser University, Burnaby, BC, Canada (Host: Dr. Lisa Craig): "Towards understanding the architecture and unraveling the many mysteries of the Type 2 Secretion System"


2010

431. March 5, 2010 – Dept. of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK (Host: Dr. Junpeng Deng): "Structural biology and unraveling the mysteries of export of cholera toxin by the Type 2 Secretion system"
432. June 28, 2010 – Gordon Conference "Bacterial Cell Surfaces", Colby Sawyer College, New London, NH, USA (Organizers: Drs. Christine Jacobs-Wagner and Jan Tommassen): "Structural Biology of the Type 2 Secretion system"
433. July 7, 2010 – Centres of Excellence Workshop "Bacterial Secretion", Talaris Conference Center, Seattle WA, USA (Organizer: Dr. Samuel Miller): "Structure and Function of the Type 2 Secretion System"
434. July 13, 2010 – Gordon Conference "Microbial Toxins and Pathogenesis", Waterville Valley, NH, USA (Organizers: Drs. Joseph Barbieri and Raph Isberg): "The fascinating properties and remaining mysteries of the Type 2 Secretion System"
435. September 16, 2010 – Dept. of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (Host: Dr. Egbert Hoiczyk): "Structural Biology in the Battle against Tropical Diseases"
436. December 7, 2010 – Zing Conference on "Structural Biology & Drug Design", Puerto Morelos, Quintana Roo, Mexico (Organizers: Drs. Tom Blundell, Chris Murray and Jim Wells): "Structural Biology and Tropical Diseases"


2011

437. February 3, 2011 – NKI-AVL Seminar, National Cancer Institute (NKI), Amsterdam, The Netherlands (Host: Dr. Piet Borst): "Structural Biology and Drug Design for Tropical Diseases"
438. March 18, 2011 – "Nozaki Memorial Lecture", Department of Biochemistry, School of Medicine, Duke University, Durham, North Carolina: "Structural Biology and Drug Design for Tropical Diseases"
439. April 15, 2011 – Seminar, Biozentrum, Basel, Switzerland (Host: Dr. Tilman Schirmer): "Structural biology of key proteins, including the type II secretion system, in drug design for tropical diseases"
440. April 26, 2011 – Seminar, School of Molecular Biosciences and Department of Chemistry, Washington State University, Pullman, WA (Host: Dr. ChulHee Khang): "Structural Biology for Drug Design against Tropical Infectious Diseases"
441. June 17, 2011 – Opening evening lecture, 15th Annual Meeting Structural Biology Network (SBNet), Tällberg, Sweden (Organizer: Torleif Härd): "Structural Biology for Drug Design against Tropical Infectious Diseases"
442. September 21, 2011 – Cold Spring Harbor Conferences Asia on "Protein Structure Based Drug Design", Suzhou, Jiangsu, China (Organizers: Joell Sussmann, Hualiang Jiang, et al.): "Structural Biology and Drug Design for Infectious Tropical Diseases"
443. December 15, 2011 – Structural Biology Interest Group Seminar, NIH Campus, Bethesda, USA. (Host: James Hurley): "Structural Biology of the Two-Membrane Spanning Type II Secretion System - Progress Made and Secrets Remaining"


2012

444. April 13, 2012 – Seminar, Bijvoet Center, University of Utrecht, Utrecht, The Netherlands (Host: Piet Gros): "Towards understanding the sophisticated two-membrane-spanning Type II Secretion System"
445. April 25, 2012 – Seminar, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA (Hosts: Mike Gretes and Andrew Karplus): "Structural Biology in Drug Design against Tropical Infectious Diseases"
446. April 27, 2012 – 17th Annual Structural Biology Symposium, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA (Symposium chairs: Werner Braun and Xiaodong Cheng): " Cholera toxin and the two-membrane-spanning Type II Secretion System"
447. June 6, 2012 – Seminar, Départments Biologie Structurale & Chimie and Microbiologie, Institut Pasteur, Paris, France (Host: Olivera Francetic): "Towards understanding the two-membrane spanning type 2 secretion system"
448. June 7, 2012 – Seminar, Départments Biologie Structurale & Chimie and Microbiologie, Institut Pasteur, Paris, France (Hosts: Olivera Francetic and Rémi Fronzes): "Structural Biology in Drug Design against Tropical Infectious Diseases"
449. June 8, 2012 – Tropical Research Unit Farewell Symposium, Christian De Duve Institute, Brussels, Belgium (Organizer: Paul Michels): "Structural Biology in Drug Design against Tropical Infectious Diseases"
450. September 3, 2012 – Symposium on "Proteins: From Methods via Structure and Function to Drug Design", Trippenhuis, KNAW, Amsterdam, The Netherlands (Organizers: Titia Sixma, Piet Gros, Andrea Mattevi, Christophe Verlinde, Bauke Dijkstra): "Reflections on Science and Society"
451. November 5-16, 2012 – United Nations University (UNU-BIOLAC) Workshop "Drug Development and Neglected Tropical Diseases", Merida, Venezuela (Organizers: Paul Michels, Juan Luis Concepcion, Luisana Avilan, Wilfredo Quiñones) - 25 lectures:

  1. Thermodynamics, Water, Hydrophobic Interactions
  2. Fundamentals of Protein Structure
  3. Proteins, Multi-Protein Complexes, Symmetry
  4. Allosteric Proteins and Conformational Changes
  5. Enzyme Kinetics, Assay Development, High Thoughput Screening
  6. Enzyme Catalytic Mechanisms and Transition State Stabilization in Drug Design
  7. Protein Purification and Purification 1
  8. Protein Purification and Purification 2
  9. Protein Crystallization and Crystal Cryoprotection
  10. Basic Protein Crystallography
  11. HIV Protease Structure-based Drug Design
  12. Inspiration from Known Modes of Drug Action 1
  13. Inspiration from Known Modes of Drug Action 2
  1. Targeting Trypanosomatid tRNA Synthetases
  2. Forces and Energies
  3. Solvation
  4. The Power of Multivalency
  5. Scoring and Docking
  6. Structure-based Drug Design for Tuberculosis
  7. Fragment-based Inhibitor Discovery
  8. HIV Reverse Transcriptase Drug Design
  9. Mechanisms of Drug Resistance 1
  10. Mechanisms of Drug Resistance 2
  11. Suicide Drugs and Prodrugs
  12. Strategies to Limit Drug Resistance


2013

452. January 11, 2013 – International Conference on "Biomolecular Forms and Functions: A celebration of 50 years of the Ramachandran map", Indian Institute of Science, Bangalore, India (Organizers: Manju Bansal, N. Srinivasan): "Structural biology of the type II secretion system of Vibrio cholerae and other pathogenic bacteria".
453. January 14-18, 2013 –Workshop "Drug Development and Infectious Diseases", School of Life Sciences, Jawaharlal Nehru University, New Delhi, India (Organizers: Rentala Madhubala and Alok Bhattacharya) (14 lectures).
454. April 22, 2013 – Infection Biology Seminar, The Center for Molecular Life Sciences, Biozentrum Universität Basel, Basel, Switzerland (Host: Jean Pieterse): "Structural Biology in Drug Design against Tropical Infectious Diseases".
455. May 20-24, 2013 – International Training Course on "Drug development and Neglected Tropical Infectious Diseases", National Center for Genetic Engineering and Biotechnology (BIOTEC), Khlong Luang, Pathum Thani, Thailand (Organizers: Wichai Pornthanakasem, Kasaporn Sukata, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong) (15 lectures).
456. Oct 28-Nov 1, 2013 – Workshop on "Drug Design and Neglected Tropical Diseases", Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos-SP, Brazil (Organizers: Rafael Guido and Artur Torres Cordeiro) (10 lectures).
457. Nov 11-12, 2013 – Advanced School on "Synchrotron Radiation Techniques and Nanotechnology: A Synergic Approach to Life Sciences and Medicine", iThemba Laboratories, Cape Town Campus, Stellenbosch, South Africa (Organizers: L. Casalis, S. Onesti, A. Laio, G. Scoles, J. Niemela, M.Maaza, I. Parker, W.-D. Schubert) (IUCr Professor; 3 lectures).

2014

458. March 3-7, 2014 – International Workshop on Structural Biology & its Application to Parasite Diseases, National Center for Cell Science & Pune University, Pune, India (Organizers: Payel Ghosh, J. K. Pall and Shekhar Mande) (12 lectures).
459. June 3, 2014 – Centre for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands (Host: Koen Dechering, TROPIQ) : "Structural Biology in Drug Design against Tropical Infectious Diseases".
460. June 6, 2014 – Dept. Architecture et Fonction des Macromolecules Biologiques, CNRS - Aix-Marseille University, Marseille, France (Host: Christian Cambillau): "Structural Biology in Unraveling Mysteries of the Type II Secretion System (T2SS)".
461. June 6, 2014 – Séminaire FR/ IHU Méditerranée Infection Timone High School of Medicine, Marseille, France (Hosts: Michel Drancourt and Christian Cambillau): "Structural Biology in Drug Design against Tropical Infectious Diseases".
462. August 8, 2014 – 23rd Congress International Union of Crystallography, Montréal, Canada (Session Chairs: Natalie Strynadka and Konstantin Korotkov) : "Multiple approaches towards understanding the type II secretion system (T2SS)".
463. November 3-8, 2014 – International Workshop on "Modern Approaches in Drug Discovery for Neglected Infectious Diseases", Institut Pasteur, Montevideo, Uruguay (Organizer: Alejandro Buschiazzo) (12 lectures).


2015

464. February 22-27, 2015 – International Workshop on "Drug Development and Neglected Tropical Infectious Diseases", Centre of Advanced Study In Crystallography and Biophysics & Bioinformatics Infrastructure Facility, University of Madras, Guindy Campus, Chennai, India (Organizer: D. Velmurugan) (11 lectures).
465. April 22, 2015 – Seminar, "Structural biology in drug design against tropical infectious diseases", Infectious Diseases Research Institute (IDRI), Seattle, WA, USA (Host: Joshua Odingo).
466. June 19, 2015 – Seminar, "Towards understanding the type II secretion system (T2SS)", Department of Chemistry, University of Oslo, Oslo, Norway (Host: Ute Krengel).
467. September 17, 2015 – Innovative Drug Design Course, Utrecht Institute of Pharmaceutical Sciences (UIPS), University of Utrecht, The Netherlands, “Inspiring modes of drug action” & “Mechanisms of drug resistance” (Host: Ed Moret).
468. September 18, 2015 – International Seminar, Utrecht Institute of Pharmaceutical Sciences (UIPS), University of Utrecht, The Netherlands, “Structural Biology in the quest for new drugs against tropical infectious diseases” (Host: Ed Moret).
469. November 9-13, 2015 – 2nd Workshop on Drug Design and Neglected Tropical Diseases, São Carlos Institute of Physics (IFSC), University of São Paulo, Sao Carlos, Brazil (Organizer: Rafael Guido) (7 lectures).


2016

470. February 1-5, 2016 – International Conference and Workshop on Structure Based Drug Designing & Application to Infectious Diseases, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State, India (Organizer: Sharmishta Banerjee) (9 lectures).
471. February 8, 2016 – University College Utrecht, Utrecht, The Netherlands: “Design and development of novel therapeutics to treat tuberculosis” (Host: Ed Moret). (2 lectures)
472. September 15, 2016 – British Society for Parasitology, Autumn Symposium 2016, Durham, UK: “A structure-guided approach to the design of trypanosomatid tRNA synthetase inhibitors”.
473. September 19, 2016 – Centre for Translational and Chemical Biology (CTCB), School of Biological Sciences, The University of Edinburgh, UK: “A structure-guided approach to the design of trypanosomatid tRNA synthetase inhibitors” (Host: Malcolm Walkinshaw).
474. September 22, 2016 – Innovative Drug Design Course, Utrecht Institute of Pharmaceutical Sciences (UIPS), University of Utrecht, The Netherlands, “Inspiring modes of drug action” & “Mechanisms of drug resistance” (Host: Ed Moret).
475. November 1-8, 2016 – International Workshop, Drug Design for Neglected Tropical Diseases, Facultad de Ciencias Exactas, Universida Nacional de La Plata, La Plata, Argentina (Organizers: Alan Talevi and Luciana Gavernet) (9 lectures).

Updated 17 January, 2017

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